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MedKoo Cat#: 412523 | Name: Cefotiam free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefotiam (free base) is one of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

Chemical Structure

Cefotiam free base
CAS#61622-34-2 (free base)

Theoretical Analysis

MedKoo Cat#: 412523

Name: Cefotiam free base

CAS#: 61622-34-2 (free base)

Chemical Formula: C18H23N9O4S3

Exact Mass: 525.1035

Molecular Weight: 525.62

Elemental Analysis: C, 41.13; H, 4.41; N, 23.98; O, 12.18; S, 18.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
66309-69-1 (2HCl) 61622-34-2 (free base)
Synonym
Cefotiam; Cefotiamum; Aspil; CGP14221E; CGP-14221E; CGP 14221E
IUPAC/Chemical Name
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-trans)-
InChi Key
QYQDKDWGWDOFFU-IUODEOHRSA-N
InChi Code
InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1
SMILES Code
O=C(C(N12)=C(CSC3=NN=NN3CCN(C)C)CS[C@]2([H])[C@H](NC(CC4=CSC(N)=N4)=O)C1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 525.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tian Y, Wang YN, Han Y, Zhang X, Hu CQ. Isolation, identification and in silico toxicity predictions of two isomers from cefotiam hydrochloride. J Pharm Biomed Anal. 2018 Sep 5;158:425-430. doi: 10.1016/j.jpba.2018.06.020. Epub 2018 Jun 18. PMID: 29945059. 2: Kan M, Wu L, Zhou XW, Jiang YF, Wu YE, Shi HY, Hao GX, Zheng Y, Su LQ, Huang X, Zhao W. Cefotiam Treatment in Children: Evidence of Subtherapeutic Levels. Ther Drug Monit. 2020 Oct;42(5):733-736. doi: 10.1097/FTD.0000000000000759. PMID: 32251152. 3: Brogard JM, Jehl F, Willemin B, Lamalle AM, Blickle JF, Monteil H. Clinical pharmacokinetics of cefotiam. Clin Pharmacokinet. 1989 Sep;17(3):163-74. doi: 10.2165/00003088-198917030-00003. PMID: 2680212. 4: Shimizu S, Chen KR, Miyakawa S. Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses. Dermatology. 1996;192(2):174-6. doi: 10.1159/000246352. PMID: 8829507. 5: Tang QX, Liu MD, Yan YY, Ye Y, Wang ZH, Zhan LF, Liao LC. [Determination of unknown impurities in cefotiam hexetil by HPLC-MS/MS]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 May;44(3):481-4, 493. Chinese. PMID: 23898540. 6: Di Nola F, Arione R, Fabiano A, Ferrea G, Leone G, Loy A, Negro F, Pavesio D, Salassa B, Soranzo ML, et al. Cefotiam, nuova cefalosporina. Ricerca microbiologica, valutazione preliminare dell'interferenza sulla fagocitosi e ricerca clinica policentrica [Cefotiam, a new cephalosporin. Microbiological research, preliminary evaluation of its effect on phagocytosis and clinical multicenter research]. Minerva Med. 1986 Nov 30;77(45-46):2163-82. Italian. PMID: 3540731. 7: Tadokoro K, Niimi N, Ohtoshi T, Nakajima K, Takafuji S, Onodera K, Suzuki S, Muranaka M. Cefotiam-induced IgE-mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature. Clin Exp Allergy. 1994 Feb;24(2):127-33. doi: 10.1111/j.1365-2222.1994.tb00208.x. PMID: 7514490. 8: Müller R, Böttger C, Wichmann G. Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients. Arzneimittelforschung. 2003;53(2):126-32. doi: 10.1055/s-0031-1297083. PMID: 12642969. 9: Imada A, Hirai S. Cefotiam hexetil. Int J Antimicrob Agents. 1995 Apr;5(2):85-99. doi: 10.1016/0924-8579(94)00038-v. PMID: 18611654. 10: Knoop M, Schütze M, Piek J, Drewelow B, Mundkowski R. Antibiotic prophylaxis in cerebrospinal fluid shunting: reassessment of Cefotiam penetration into human CSF. Zentralbl Neurochir. 2007 Feb;68(1):14-8. doi: 10.1055/s-2007-968168. PMID: 17487803.