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MedKoo Cat#: 413677 | Name: Dibrospidium Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dibrospidium Free Base is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correlate with spirobromine antitumor activity. Spirobromin is superior to prospidin by the power of the anti-inflammatory effect. Spyrobromin can diminish the latent period of the development of tumours in the experimental rats at intraperitoneal administration. At intragastric administration of the drug no decrease was noted in the latent period and no increase of tumours was observed in the experimental groups of the animals as compared with control. Dibrospidium has been examined for the treatment of bone cancer. The oral route of administration is the most safe with respect to the oncogenic risk. It was noted that spirobromin exerted the most pronounced toxic action on erythrocytes. Dibrospidium is used for the treatment of acute leukemias (mainly in combination therapy), malignant lymphomas, laryngeal cancer and skin reticulosis.

Chemical Structure

Dibrospidium Free Base
Dibrospidium Free Base
CAS#86641-78-3 (free base)

Theoretical Analysis

MedKoo Cat#: 413677

Name: Dibrospidium Free Base

CAS#: 86641-78-3 (free base)

Chemical Formula: C18H32Br2N4O22+

Exact Mass: 494.0881

Molecular Weight: 496.29

Elemental Analysis: C, 43.56; H, 6.50; Br, 32.20; N, 11.29; O, 6.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
86641-78-3 (free base) 86641-76-1 (Cl)
Synonym
Dibrospidium Free Base; Dibrospidium cation; Dibrospidium ion
IUPAC/Chemical Name
3,12-Diaza-6,9-diazoniadispiro(5.2.5.2)hexadecane, 3,12-bis(3-bromo-1-oxopropyl)-
InChi Key
JXEICPOBKSQAIU-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H32Br2N4O2/c19-3-1-17(25)21-5-9-23(10-6-21)13-15-24(16-14-23)11-7-22(8-12-24)18(26)2-4-20/h1-16H2/q+2
SMILES Code
O=C(N(CC1)CC[N+]1(CC2)CC[N+]32CCN(C(CCBr)=O)CC3)CCBr
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 496.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bohn AA, de Morais HA. A Quick Reference on Chloride. Vet Clin North Am Small Anim Pract. 2017 Mar;47(2):219-222. doi: 10.1016/j.cvsm.2016.10.008. Epub 2016 Dec 20. PMID: 28007306. 2: Zhang JJ, Jacob TJ. The role of chloride in the lens of the eye. Exp Physiol. 1997 Mar;82(2):245-59. doi: 10.1113/expphysiol.1997.sp004020. PMID: 9129939. 3: Zhang F, Ma C, Wang Y, Liu W, Liu X, Zhang H. Fluorescent probes for chloride ions in biological samples. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Dec 5;205:428-434. doi: 10.1016/j.saa.2018.07.060. Epub 2018 Jul 21. PMID: 30053636. 4: Chang H, Mu S. Detecting the Water-soluble Chloride Distribution of Cement Paste in a High-precision Way. J Vis Exp. 2017 Nov 21;(129):56268. doi: 10.3791/56268. PMID: 29286369; PMCID: PMC5755450. 5: Musolino SV, Coulter DT, Tedla H. Cesium chloride: dispersibility or security? Health Phys. 2011 May;100(5):459-61. doi: 10.1097/HP.0b013e31820c6657. PMID: 21451314. 6: Müller V, Oren A. Metabolism of chloride in halophilic prokaryotes. Extremophiles. 2003 Aug;7(4):261-6. doi: 10.1007/s00792-003-0332-9. Epub 2003 May 1. PMID: 12728360. 7: Smith DGM, Williams SJ. A carbon tetrachloride-free synthesis of N-phenyltrifluoroacetimidoyl chloride. Carbohydr Res. 2017 Oct 10;450:10-11. doi: 10.1016/j.carres.2017.08.004. Epub 2017 Aug 10. PMID: 28822278. 8: Carugo O. Buried chloride stereochemistry in the Protein Data Bank. BMC Struct Biol. 2014 Sep 23;14:19. doi: 10.1186/s12900-014-0019-8. PMID: 25928393; PMCID: PMC4582432. 9: Saha S, Prakash V, Halder S, Chakraborty K, Krishnan Y. A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells. Nat Nanotechnol. 2015 Jul;10(7):645-51. doi: 10.1038/nnano.2015.130. Epub 2015 Jun 22. PMID: 26098226. 10: Robaina NF, Feiteira FN, Cassella AR, Cassella RJ. Determination of chloride in brazilian crude oils by ion chromatography after extraction induced by emulsion breaking. J Chromatogr A. 2016 Aug 5;1458:112-7. doi: 10.1016/j.chroma.2016.06.066. Epub 2016 Jun 21. PMID: 27388656. 11: Zamoyski VL, Grigoriev VV. Key role of external chloride ions in regulation of fast sodium channels in rat cerebellum Purkinje neurons. Dokl Biochem Biophys. 2017 Nov;477(1):382-384. doi: 10.1134/S1607672917060102. Epub 2018 Jan 3. PMID: 29297130. 12: Manz F. Alimentärer Chloridmangel bei Frühgeborenen? [Dietary chloride deficiency in premature infants?]. Klin Padiatr. 1985 Jul-Aug;197(4):259-62. German. doi: 10.1055/s-2008-1033979. PMID: 4046481. 13: Heathcote RD. Acetylcholine-gated and chloride conductance channel expression in rat muscle membrane. J Physiol. 1989 Jul;414:473-97. doi: 10.1113/jphysiol.1989.sp017699. PMID: 2481727; PMCID: PMC1189153. 14: Rosen RA, Julian BA, Dubovsky EV, Galla JH, Luke RG. On the mechanism by which chloride corrects metabolic alkalosis in man. Am J Med. 1988 Mar;84(3 Pt 1):449-58. doi: 10.1016/0002-9343(88)90265-3. PMID: 2450456. 15: Zhang Z, Wang L, Lu Y. [Determination of sodium and chloride in hogwash oil and their molar ratio by ion chromatography]. Se Pu. 2012 Nov;30(11):1113-6. Chinese. doi: 10.3724/sp.j.1123.2012.08053. PMID: 23451512. 16: Al-Bander SY, Nix L, Katz R, Korn M, Sebastian A. Food chloride distribution in nature and its relation to sodium content. J Am Diet Assoc. 1988 Apr;88(4):472-5. PMID: 3351167. 17: Arosio D, Ricci F, Marchetti L, Gualdani R, Albertazzi L, Beltram F. Simultaneous intracellular chloride and pH measurements using a GFP-based sensor. Nat Methods. 2010 Jul;7(7):516-8. doi: 10.1038/nmeth.1471. Epub 2010 Jun 27. PMID: 20581829. 18: Coppock CE, Aguirre RA, Chase LE, Lake GB, Oltenacu EA, McDowell RE, Fettman MJ, Woods ME. Effect of a low chloride diet on lactating Holstein cows. J Dairy Sci. 1979 May;62(5):723-31. doi: 10.3168/jds.S0022-0302(79)83315-9. PMID: 457994. 19: Verkman AS. Development and biological applications of chloride-sensitive fluorescent indicators. Am J Physiol. 1990 Sep;259(3 Pt 1):C375-88. doi: 10.1152/ajpcell.1990.259.3.C375. PMID: 2205105. 20: Felder CC, Robillard JE, Roy S 3rd, Jose PA. Severe chloride deficiency in the neonate: the canine puppy as an animal model. Pediatr Res. 1987 May;21(5):497-501. doi: 10.1203/00006450-198705000-00015. PMID: 3588090.