Synonym
HOE-166 HCl; HOE166 HCl; HOE 166 HCl; HOE-166 hydrochloride
IUPAC/Chemical Name
2H-1,4-Benzothiazin-3(4H)-one, 4-methyl-2-(1-methylethyl)-2-(2-(4-(4-(2-(3,4,5-trimethoxyphenyl)ethyl)-1-piperazinyl)butyl)phenyl)-, dihydrochloride, (R)-
InChi Key
HQTMLRUQTHILKM-CHKASDEDSA-N
InChi Code
InChI=1S/C37H49N3O5S.2ClH/c1-27(2)37(36(41)38(3)30-14-8-10-16-34(30)46-37)29-13-7-9-15-31(29)45-24-12-11-18-39-20-22-40(23-21-39)19-17-28-25-32(42-4)35(44-6)33(26-28)43-5;;/h7-10,13-16,25-27H,11-12,17-24H2,1-6H3;2*1H/t37-;;/m1../s1
SMILES Code
Cl.Cl.COc1cc(CCN2CCN(CCCCOc3ccccc3[C@]4(Sc5ccccc5N(C)C4=O)C(C)C)CC2)cc(OC)c1OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
704.79
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Striessnig J, Meusburger E, Grabner M, Knaus HG, Glossmann H, Kaiser J, Schölkens B, Becker R, Linz W, Henning R. Evidence for a distinct Ca2+ antagonist receptor for the novel benzothiazinone compound HOE 166. Naunyn Schmiedebergs Arch Pharmacol. 1988 Mar;337(3):331-40. doi: 10.1007/BF00168847. PMID: 2839780.
2. Qar J, Barhanin J, Romey G, Henning R, Lerch U, Oekonomopulos R, Urbach H, Lazdunski M. A novel high affinity class of Ca2+ channel blockers. Mol Pharmacol. 1988 Apr;33(4):363-9. PMID: 2965787.
3. Lee TH, Cho YH, Lee JD, Yang WI, Shin JL, Lee MG. Enhanced antitumor effect of dendritic cell based immunotherapy after intratumoral injection of radionuclide Ho-166 against B16 melanoma. Immunol Lett. 2006 Jul 15;106(1):19-26. doi: 10.1016/j.imlet.2006.03.007. Epub 2006 Apr 18. PMID: 16647143.
