MedKoo Cat#: 464347 | Name: Hodgkinsine trimethyl iodide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hodgkinsine trimethyl is a trimethylated form of hodgkinsine.

Chemical Structure

Hodgkinsine trimethyl iodide
Hodgkinsine trimethyl iodide
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464347

Name: Hodgkinsine trimethyl iodide

CAS#: unknown

Chemical Formula: C36H47I3N6

Exact Mass:

Molecular Weight: 944.53

Elemental Analysis: C, 45.78; H, 5.02; I, 40.31; N, 8.90

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Related CAS #
No Data
Synonym
Hodgkinsine trimethyl iodide;
IUPAC/Chemical Name
(3aS,3'aR,3''aR,8aS,8'aR,8''aR)-1,1,1',1',1'',1''-hexamethyl-2,2',2'',3,3',3'',8,8a,8',8'a,8'',8''a-dodecahydro-1H,1'H,1''H-[3a,3'a:7',3''a-terpyrrolo[2,3-b]indole]-1,1',1''-triium iodide
InChi Key
FZTJJKQLSAHPSH-KRJYFQADSA-K
InChi Code
InChI=1S/C36H47N6.3HI/c1-40(2)21-18-34(24-12-7-9-16-28(24)37-31(34)40)26-14-11-15-27-30(26)39-33-36(27,20-23-42(33,5)6)35-19-22-41(3,4)32(35)38-29-17-10-8-13-25(29)35;;;/h7-17,31-33,37-39H,18-23H2,1-6H3;3*1H/q+3;;;/p-3/t31-,32+,33-,34-,35-,36+;;;/m1.../s1
SMILES Code
[H][C@@]12[N+](C)(CC[C@]1(C3=C4N[C@]([H])([N+](C)(CC5)C)[C@@]5([C@]67C8=CC=CC=C8N[C@]6([N+](C)(CC7)C)[H])C4=CC=C3)C9=CC=CC=C9N2)C.[I-].[I-].[I-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Hodgkinsine trimethyl is a trimethylated form of hodgkinsine.
In vitro activity:
TBD
In vivo activity:
Hodgkinsine shows a potent dose-dependent analgesic activity against capsaicin-induced pain, indicating the participation of NMDA receptors in hodgkinsine-induced analgesia. Reference: Planta Med. 2000 Dec;66(8):770-2. https://pubmed.ncbi.nlm.nih.gov/11199142/

Preparing Stock Solutions

The following data is based on the product molecular weight 944.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Amador TA, Verotta L, Nunes DS, Elisabetsky E. Antinociceptive profile of hodgkinsine. Planta Med. 2000 Dec;66(8):770-2. doi: 10.1055/s-2000-9604. PMID: 11199142.
In vitro protocol:
TBD
In vivo protocol:
1. Amador TA, Verotta L, Nunes DS, Elisabetsky E. Antinociceptive profile of hodgkinsine. Planta Med. 2000 Dec;66(8):770-2. doi: 10.1055/s-2000-9604. PMID: 11199142.