MedKoo Cat#: 530251 | Name: Tazomeline citrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tazomeline citrate is used for alzheimer's disease treatment (Cholinergic Agonist).

Chemical Structure

Tazomeline citrate
Tazomeline citrate
CAS#175615-45-9 (citrate)

Theoretical Analysis

MedKoo Cat#: 530251

Name: Tazomeline citrate

CAS#: 175615-45-9 (citrate)

Chemical Formula: C20H31N3O7S2

Exact Mass: 489.1603

Molecular Weight: 489.60

Elemental Analysis: C, 49.06; H, 6.38; N, 8.58; O, 22.87; S, 13.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Tazomeline citrate
IUPAC/Chemical Name
3-(4-(Hexylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine citrate (1:1)
InChi Key
WIOWZFAHNWMORW-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H23N3S2.C6H8O7/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h8H,3-7,9-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES Code
CN1CCC=C(C2=NSN=C2SCCCCCC)C1.OC(C(O)=O)(CC(O)=O)CC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 489.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jangir N, Padhi SK. Immobilized Baliospermum montanum hydroxynitrile lyase catalyzed synthesis of chiral cyanohydrins. Bioorg Chem. 2018 Nov 19;84:32-40. doi: 10.1016/j.bioorg.2018.11.017. [Epub ahead of print] PubMed PMID: 30481644. 2: Yi J, Hu H, Shi P, Shi S, Zhao J, Xu L, Yang W, Li B, Zhu J, Zou S. Differential analysis of quantitative proteome and acetyl-proteome profiling between premenopausal and postmenopausal ovarian tissues. Clin Proteomics. 2018 Nov 16;15:36. doi: 10.1186/s12014-018-9214-0. eCollection 2018. PubMed PMID: 30479583; PubMed Central PMCID: PMC6238338. 3: Goldfarb DS. Empiric therapy for kidney stones. Urolithiasis. 2018 Nov 26. doi: 10.1007/s00240-018-1090-6. [Epub ahead of print] Review. PubMed PMID: 30478476. 4: Ma C, Tian X, Kim JP, Xie D, Ao X, Shan D, Lin Q, Hudock MR, Bai X, Yang J. Citrate-based materials fuel human stem cells by metabonegenic regulation. Proc Natl Acad Sci U S A. 2018 Nov 26. pii: 201813000. doi: 10.1073/pnas.1813000115. [Epub ahead of print] PubMed PMID: 30478052. 5: Azhar A, Young C, Kaneti YV, Yamauchi Y, Badjah AY, Naushad M, Habila M, Wabaidur S, Alothman ZA, Kim J. Cyano-Bridged Cu-Ni Coordination Polymer Nanoflakes and Their Thermal Conversion to Mixed Cu-Ni Oxides. Nanomaterials (Basel). 2018 Nov 23;8(12). pii: E968. doi: 10.3390/nano8120968. PubMed PMID: 30477166. 6: Hatabu N, Amano N, Mori J, Hasegawa Y, Matsuura H, Sumitomo N, Nishizawa K, Suzuki M, Katakura S, Kanamoto N, Kamimaki T, Ishii T, Hasegawa T. Pubertal Development and Pregnancy Outcomes in 46,XX Patients with Nonclassic Lipoid Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 2018 Nov 23. doi: 10.1210/jc.2018-01752. [Epub ahead of print] PubMed PMID: 30476142. 7: Visage R, Kaiser N, Williams M, Kim A. Oral Methods of Urinary Alkalinization for High-dose Methotrexate Administration: Alternatives to Intravenous Sodium Bicarbonate During a Critical Drug Shortage. J Pediatr Hematol Oncol. 2018 Nov 20. doi: 10.1097/MPH.0000000000001348. [Epub ahead of print] PubMed PMID: 30475303. 8: Hornstrup T, Løwenstein FT, Larsen MA, Helge EW, Póvoas S, Helge JW, Nielsen JJ, Fristrup B, Andersen JL, Gliemann L, Nybo L, Krustrup P. Cardiovascular, muscular, and skeletal adaptations to recreational team handball training: a randomized controlled trial with young adult untrained men. Eur J Appl Physiol. 2018 Nov 24. doi: 10.1007/s00421-018-4034-5. [Epub ahead of print] PubMed PMID: 30474740. 9: Ma Y, Cui Y, Du L, Liu X, Xie X, Chen N. Identification and application of a growth-regulated promoter for improving L-valine production in Corynebacterium glutamicum. Microb Cell Fact. 2018 Nov 24;17(1):185. doi: 10.1186/s12934-018-1031-7. PubMed PMID: 30474553. 10: Liew KB, Peh KK. Stability indicating HPLC method for simultaneous quantification of sildenafil citrate and dapoxetine hydrochloride in Pharmaceutical products. Pak J Pharm Sci. 2018 Nov;31(6):2515-2522. PubMed PMID: 30473526. 11: Chung MY, Song JH, Lee J, Shin EJ, Park JH, Lee SH, Hwang JT, Choi HK. Tannic acid, a novel histone acetyltransferase inhibitor, prevents non-alcoholic fatty liver disease both in vivo and in vitro model. Mol Metab. 2018 Nov 10. pii: S2212-8778(18)30934-7. doi: 10.1016/j.molmet.2018.11.001. [Epub ahead of print] PubMed PMID: 30473486. 12: Serrano Vicente J, Parras Castañera E, Infante Torre JR, Rayo Madrid JI, García Bernardo L, Caballero Moreno M, Martínez Esteve A, Muñoz Sanz A. 67-Gallium SPECT/CT in febrile syndromes of unknown origin. Rev Esp Med Nucl Imagen Mol. 2018 Nov - Dec;37(6):354-358. doi: 10.1016/j.remn.2018.05.003. Epub 2018 Jun 28. English, Spanish. PubMed PMID: 30473055. 13: Zúniga-Navarrete F, Flores-Ramirez G, Quevedo-Díaz M, Škultéty L. Counting of viable C. burnetii cells by quantitative reverse transcription PCR using a recombinant plasmid (pCB-dotA) as a standard. Acta Virol. 2018;62(4):409-414. doi: 10.4149/av_2018_409. PubMed PMID: 30472871. 14: Flaherty EJ, Lum GB, DeEll JR, Subedi S, Shelp BJ, Bozzo GG. Metabolic alterations in postharvest pear fruit as influenced by 1-methylcyclopropene and controlled atmosphere storage. J Agric Food Chem. 2018 Nov 25. doi: 10.1021/acs.jafc.8b04912. [Epub ahead of print] PubMed PMID: 30472842. 15: Crowley SV, Kelly AL, O'Mahony JA, Lucey JA. Colloidal properties of protein complexes formed in β-casein concentrate solutions as influenced by heating and cooling in the presence of different solutes. Colloids Surf B Biointerfaces. 2018 Oct 28;174:343-351. doi: 10.1016/j.colsurfb.2018.10.067. [Epub ahead of print] PubMed PMID: 30472620. 16: Niesen AM, Rossow HA. The effects of relative gain and age on peripheral blood mononuclear cell mitochondrial enzyme activity in preweaned Holstein and Jersey calves. J Dairy Sci. 2018 Nov 21. pii: S0022-0302(18)31082-8. doi: 10.3168/jds.2018-15092. [Epub ahead of print] PubMed PMID: 30471911. 17: Guerra A, Ticinesi A, Allegri F, Nouvenne A, Prati B, Pinelli S, Merli R, Tana C, Lauretani F, Aloe R, Borghi L, Meschi T. Insights about urinary hippuric and citric acid as biomarkers of fruit and vegetable intake in patients with kidney stones: The role of age and sex. Nutrition. 2018 Aug 22;59:83-89. doi: 10.1016/j.nut.2018.07.112. [Epub ahead of print] PubMed PMID: 30471528. 18: Lin YS, Saputra F, Chen YC, Hu SY. Dietary administration of Bacillus amyloliquefaciens R8 reduces hepatic oxidative stress and enhances nutrient metabolism and immunity against Aeromonas hydrophila and Streptococcus agalactiae in zebrafish (Danio rerio). Fish Shellfish Immunol. 2018 Nov 21. pii: S1050-4648(18)30766-6. doi: 10.1016/j.fsi.2018.11.047. [Epub ahead of print] PubMed PMID: 30471337. 19: Rosa LT, Dix SR, Rafferty JB, Kelly DJ. A New Mechanism for High-Affinity Uptake of C4-Dicarboxylates in Bacteria Revealed by the Structure of Rhodopseudomonas palustris MatC (RPA3494), a Periplasmic Binding-Protein of the Tripartite Tricarboxylate Transporter (TTT) Family. J Mol Biol. 2018 Nov 21. pii: S0022-2836(18)30977-X. doi: 10.1016/j.jmb.2018.11.016. [Epub ahead of print] PubMed PMID: 30471256. 20: Li W, Lin J, Shi Z, Wen J, Li Y, Liu Z, Diao A. Clomiphene citrate induces nuclear translocation of the TFEB transcription factor and triggers apoptosis by enhancing lysosomal membrane permeabilization. Biochem Pharmacol. 2018 Nov 21. pii: S0006-2952(18)30494-5. doi: 10.1016/j.bcp.2018.11.016. [Epub ahead of print] PubMed PMID: 30471247.