ML095 HCl | CAS#1135318-57-8 | PLAP inhibitor

MedKoo Cat#: 555937 | Name: ML095 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML095, also known as CID-25067483 and MLS-0315848, is a PLAP inhibitor (placental alkaline phosphatase inhibitor). The IC50 valuess of ML095 against PLAP, TNAP and IAP are 2.1, >100 and 53 μM, respectively.

Chemical Structure

ML095 HCl

CAS#1135318-57-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 555937

Name: ML095 HCl

CAS#: 1135318-57-8 (HCl)

Chemical Formula: C13H15ClN2O3

Exact Mass:

Molecular Weight: 282.72

Elemental Analysis: C, 55.23; H, 5.35; Cl, 12.54; N, 9.91; O, 16.98

Price and Availability

Size	Price	Availability
50mg	USD 250.00	2 Weeks
100mg	USD 450.00	2 Weeks
200mg	USD 750.00	2 Weeks
500mg	USD 1,650.00	2 Weeks
1g	USD 2,950.00	2 Weeks
2g	USD 5,250.00	2 Weeks

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Related CAS #

1135318-57-8 (HCl)

Synonym

ML095 HCl; ML-095; ML 095; CID-25067483 hydrochloride; CID25067483; CID 25067483; MLS-0315848 hydrochloride; MLS 0315848; MLS0315848;

IUPAC/Chemical Name

1-(3,4-Dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)-Ethanone hydrochloride

InChi Key

VTSPJLHFXSMCCC-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H14N2O3.ClH/c1-2-13-14-5-6-15(13)8-12(18)9-3-4-10(16)11(17)7-9;/h3-7,16-17H,2,8H2,1H3;1H

SMILES Code

CCC1=NC=CN1CC(C2=CC=C(O)C(O)=C2)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Placental alkaline phosphatase (PLAP) is highly expressed in primate placental tissue. Its biological function and relevance are still unknown, but PLAP-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers. Consequently, the identification of PLAP-specific inhibitors with selectivity over tissue non-specific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) may provide the necessary tools to characterize its biological role.

Product Data

Product Data

Instruction

View handling instruction

Biological target:

ML095 is a biochemical inhibitor of PLAP.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	10.0	35.37

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 282.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

Lanier M, Cashman J, Sergienko E, Garcia X, Brown B, Rascon J, Narisawa S, Simao AM, Millán JL, Stonich D, Su Y, Dahl R, Chung TDY. Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 2. 2009 May 16 [updated 2010 Sep 2]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 21433367.