Hematoporphyrin | CAS# 14459-29-1 | Biochemical

MedKoo Cat#: 576232 | Name: Hematoporphyrin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hematoporphyrin is an iron-free derivative of heme with 4 methyl groups, 2 hydroxyethyl groups, and 2 propionic acid groups attached to the pyrrole rings. Some of these photosensitizing agents are used in the phototherapy of malignant neoplasms.

Chemical Structure

Hematoporphyrin

CAS#14459-29-1 (free base)

Theoretical Analysis

MedKoo Cat#: 576232

Name: Hematoporphyrin

CAS#: 14459-29-1 (free base)

Chemical Formula: C34H38N4O6

Exact Mass: 598.2791

Molecular Weight: 598.70

Elemental Analysis: C, 68.21; H, 6.40; N, 9.36; O, 16.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

17696-69-4 (2HCl) 6033-50-7 (HCl) 14459-29-1 (free base)

Synonym

Hematoporphyrin; Haematoporphyrin; Hematoporphyrin I; Hematoporphyrin IX (6CI); Photodyn; Hemoporfin; NSC59265; NSC 59265; NSC-59265

IUPAC/Chemical Name

2,18-Porphinedipropionic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl- (VAN) (8CI)

InChi Key

UJKPHYRXOLRVJJ-AMPAVEGJSA-N

InChi Code

InChI=1S/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,36-37,39-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-

SMILES Code

CC(O)c1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)C(=C5CCC(=O)O)C)c(CCC(=O)O)c4C)c(C)c3C(C)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 598.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Kessel D. Hematoporphyrin and HPD: photophysics, photochemistry and phototherapy. Photochem Photobiol. 1984 Jun;39(6):851-9. doi: 10.1111/j.1751-1097.1984.tb08871.x. PMID: 6235529. 2. Lei TC, Glazner GF, Duffy M, Scherrer L, Pendyala S, Li B, Wang X, Wang H, Huang Z. Optical properties of hematoporphyrin monomethyl ether (HMME), a PDT photosensitizer. Photodiagnosis Photodyn Ther. 2012 Sep;9(3):232-42. doi: 10.1016/j.pdpdt.2012.01.003. Epub 2012 Feb 10. PMID: 22959803.