MedKoo Cat#: 413606 | Name: Dexefaroxan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dexefaroxan is an alpha(2)-adrenoceptor antagonist.

Chemical Structure

 Dexefaroxan
Dexefaroxan
CAS#143249-88-1

Theoretical Analysis

MedKoo Cat#: 413606

Name: Dexefaroxan

CAS#: 143249-88-1

Chemical Formula: C13H16N2O

Exact Mass: 216.1263

Molecular Weight: 216.28

Elemental Analysis: C, 72.19; H, 7.46; N, 12.95; O, 7.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dexefaroxan; UNII-F751MO69EV
IUPAC/Chemical Name
( )-(R)-2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-2-imidazoline.
InChi Key
RATZLMXRALDSJW-CYBMUJFWSA-N
InChi Code
InChI=1S/C13H16N2O/c1-2-13(12-14-7-8-15-12)9-10-5-3-4-6-11(10)16-13/h3-6H,2,7-9H2,1H3,(H,14,15)/t13-/m1/s1
SMILES Code
CC[C@@]1(C2=NCCN2)OC3=CC=CC=C3C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 216.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chopin P, Colpaert FC, Marien M. Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents. J Pharmacol Exp Ther. 2002 Apr;301(1):187-96. doi: 10.1124/jpet.301.1.187. PMID: 11907173. 2: Debeir T, Marien M, Ferrario J, Rizk P, Prigent A, Colpaert F, Raisman-Vozari R. In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. Exp Neurol. 2004 Dec;190(2):384-95. doi: 10.1016/j.expneurol.2004.08.023. PMID: 15530877. 3: Rizk P, Salazar J, Raisman-Vozari R, Marien M, Ruberg M, Colpaert F, Debeir T. The alpha2-adrenoceptor antagonist dexefaroxan enhances hippocampal neurogenesis by increasing the survival and differentiation of new granule cells. Neuropsychopharmacology. 2006 Jun;31(6):1146-57. doi: 10.1038/sj.npp.1300954. PMID: 16292321. 4: Debeir T, Marien M, Chopin P, Martel JC, Colpaert F, Raisman-Vozari R. Protective effects of the alpha 2-adrenoceptor antagonist, dexefaroxan, against degeneration of the basalocortical cholinergic system induced by cortical devascularization in the adult rat. Neuroscience. 2002;115(1):41-53. doi: 10.1016/s0306-4522(02)00406-2. PMID: 12401320. 5: Bauer S, Moyse E, Jourdan F, Colpaert F, Martel JC, Marien M. Effects of the alpha 2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death. Neuroscience. 2003;117(2):281-91. doi: 10.1016/s0306-4522(02)00757-1. PMID: 12614670. 6: Chopin P, Debeir T, Raisman-Vozari R, Colpaert FC, Marien MR. Protective effect of the alpha2-adrenoceptor antagonist, dexefaroxan, against spatial memory deficit induced by cortical devascularization in the adult rat. Exp Neurol. 2004 Jan;185(1):198-200. doi: 10.1016/j.expneurol.2003.09.010. PMID: 14697331. 7: Villégier AS, Drouin C, Bizot JC, Marien M, Glowinski J, Colpaërt F, Tassin JP. Stimulation of postsynaptic alpha1b- and alpha2-adrenergic receptors amplifies dopamine-mediated locomotor activity in both rats and mice. Synapse. 2003 Dec 15;50(4):277-84. doi: 10.1002/syn.10267. PMID: 14556232. 8: Estrade L, Cassel JC, Parrot S, Duchamp-Viret P, Ferry B. Microdialysis Unveils the Role of the α2-Adrenergic System in the Basolateral Amygdala during Acquisition of Conditioned Odor Aversion in the Rat. ACS Chem Neurosci. 2019 Apr 17;10(4):1929-1934. doi: 10.1021/acschemneuro.8b00314. Epub 2018 Sep 10. PMID: 30179513. 9: Francis BM, Yang J, Hajderi E, Brown ME, Michalski B, McLaurin J, Fahnestock M, Mount HT. Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease. Neuropsychopharmacology. 2012 Jul;37(8):1934-44. doi: 10.1038/npp.2012.40. Epub 2012 Apr 11. PMID: 22491352; PMCID: PMC3376325. 10: Pauwels PJ, Colpaert FC. Disparate ligand-mediated Ca(2+) responses by wild- type, mutant Ser(200)Ala and Ser(204)Ala alpha(2A)-adrenoceptor: G(alpha15) fusion proteins: evidence for multiple ligand-activation binding sites. Br J Pharmacol. 2000 Aug;130(7):1505-12. doi: 10.1038/sj.bjp.0703455. PMID: 10928951; PMCID: PMC1572214.