Synonym
Difenpiramide; Z-876
IUPAC/Chemical Name
(1,1'-Biphenyl)-4-acetamide, N-2-pyridinyl- (9CI)
InChi Key
PWHROYKAGRUWDQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H16N2O/c22-19(21-18-8-4-5-13-20-18)14-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-13H,14H2,(H,20,21,22)
SMILES Code
C(Nc1ncccc1)(=O)Cc1ccc(cc1)c1ccccc1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
0.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Varin T, Godfrey AG, Masquelin T, Nicolaou CA, Evans DA, Vieth M. Discovery of selective RIO2 kinase small molecule ligand. Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1630-6. doi: 10.1016/j.bbapap.2015.04.006. Epub 2015 Apr 17. PubMed PMID: 25891899.
2: Lee DK, Shin JS. [A clinical study on the analgesic effectiveness of diphenpyramide in patients with orofacial pain following oral surgery]. Taehan Chikkwa Uisa Hyophoe Chi. 1987 Sep;25(9):873-83. Korean. PubMed PMID: 3507461.
3: Jochems OB, Janbroers JM. Diphenpyramide: a review of its pharmacology and anti-inflammatory effects. Pharmatherapeutica. 1986;4(7):429-41. PubMed PMID: 3515370.
4: Lunghi F, Blasi M, Frasson P, Lunghi M, Giusti P. [Evaluation of the therapeutic activity and tolerability of difenpiramide in otorhinolaryngology]. Clin Ter. 1982 Dec 31;103(6):635-45. Italian. PubMed PMID: 7160146.
5: Cortini C, Campieri M, Brignola C, Bazzocchi G, Squillantini P. [Gastric tolerance of diphenpyramide after long-term treatment. Evaluation of the electric potential difference in the stomach]. Clin Ter. 1982 Dec 15;103(5):521-5. Italian. PubMed PMID: 7160144.
6: Dovigo L, Tartarini G, Cavalieri GP, Mazzi P, Cavilieri GP, Belluzzi D, Corazza G. [Clinical study of difenpiramide in the treatment of degenerative and inflammatory arthropathies]. Clin Ter. 1982 Apr 30;101(2):137-42. Italian. PubMed PMID: 7094545.
7: Lorenzini P. [Clinical aspects and microcirculation findings in the treatment of arthrotic arthropathies with difenpiramide]. Minerva Med. 1981 Nov 14;72(45):3003-12. Italian. PubMed PMID: 7312201.
8: Rainaldi P, Santoprete G. [Vertigo in vertebrobasilar insufficiency: experience with combined physical and pharmacological therapy]. Clin Ter. 1981 Aug 15;98(3):289-98. Italian. PubMed PMID: 7285539.
9: Signorelli I, Garbarino G. [The use of difenpiramide in local or circumscribed inflammation in obstetrics and gynecology]. Clin Ter. 1981 Jul 15;98(1):37-46. Italian. PubMed PMID: 7249571.
10: Trebbi A, Filippi G. Physicochemical profile of a new antiinflammatory drug: difenpiramide. Boll Chim Farm. 1979 Dec;118(12):729-38. PubMed PMID: 552255.
11: Fumagalli M, Montrone F, Vernazza M, Tirrito M, Santandrea S, Caruso I. [Diphenpiramide in the treatment of rheumatoid arthritis: short-time double-blind study of its comparison with indomethacin]. Clin Ter. 1979 Jun 30;89(6):581-8. Italian. PubMed PMID: 397027.
12: Ortolani C, Bellasio G, Bertini M, Pastorello E. [Study of the therapeutic effectiveness of diphenpyramide in the treatment of arthropathies, as compared with acetylsalicylic acid]. Clin Ter. 1979 May 31;89(4):391-405. Italian. PubMed PMID: 535319.
13: Gugliotta L, Guarini A. [Anti-inflammatory drugs and platelet anti-aggregation activity: difenpiramide]. G Clin Med. 1976 Nov-Dec;57(11-12):408-15. Italian. PubMed PMID: 1028655.
