Aflatoxin B2 | CAS#7220-81-7 | Hepatocarcinogen & Food contaminant

MedKoo Cat#: 464311 | Name: Aflatoxin B2

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aflatoxin B2 is a hepatocarcinogen. It is a food contaminant produced by Aspergillus flavus, a common soil fungus. Aflatoxin B2/AFB2 may have dangerous hepatotoxic, teratogenic and carcinogenic actions on various forms of livestock.

Chemical Structure

Aflatoxin B2

CAS#7220-81-7

Theoretical Analysis

MedKoo Cat#: 464311

Name: Aflatoxin B2

CAS#: 7220-81-7

Chemical Formula: C17H14O6

Exact Mass: 314.0790

Molecular Weight: 314.29

Elemental Analysis: C, 64.97; H, 4.49; O, 30.54

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 270.00	2 Weeks
5mg	USD 680.00	2 Weeks

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Related CAS #

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Synonym

Aflatoxin B2; Aflatoxin-B2; AFB2; AF B2; AF-B2;

IUPAC/Chemical Name

(6aR,9aS)-4-methoxy-2,3,6a,8,9,9a-hexahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione

InChi Key

WWSYXEZEXMQWHT-WNWIJWBNSA-N

InChi Code

InChI=1S/C17H14O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h6,8,17H,2-5H2,1H3/t8-,17+/m0/s1

SMILES Code

COc1c2c(OC(C3=C2CCC3=O)=O)c4c(O[C@H]5OCC[C@H]54)c1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 314.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 32983001; PMCID: PMC7480073. 5: Tanveer ZI, Huang Q, Liu L, Jiang K, Nie D, Pan H, Chen Y, Liu X, Luan L, Han Z, Wu Y. Reduced graphene oxide-zinc oxide nanocomposite as dispersive solid- phase extraction sorbent for simultaneous enrichment and purification of multiple mycotoxins in Coptidis rhizoma (Huanglian) and analysis by liquid chromatography tandem mass spectrometry. J Chromatogr A. 2020 Sep 1;1630:461515. doi: 10.1016/j.chroma.2020.461515. Epub ahead of print. PMID: 32911177. 6: Pallarés N, Berrada H, Fernández-Franzón M, Ferrer E. Risk Assessment and Mitigation of the Mycotoxin Content in Medicinal Plants by the Infusion Process. Plant Foods Hum Nutr. 2020 Sep;75(3):362-368. doi: 10.1007/s11130-020-00820-4. PMID: 32388807. 7: Valente S, Meloni GR, Prencipe S, Spigolon N, Somenzi M, Fontana M, Gullino ML, Spadaro D. Effect of Drying Temperatures and Exposure Times on Aspergillus flavus Growth and Aflatoxin Production on Artificially Inoculated Hazelnuts. J Food Prot. 2020 Jul 1;83(7):1241-1247. doi: 10.4315/JFP-20-061. PMID: 32221534. 8: Liu Y, Mao H, Hu C, Tron T, Lin J, Wang J, Sun B. Molecular docking studies and in vitro degradation of four aflatoxins (AFB1 , AFB2 , AFG1 , and AFG2 ) by a recombinant laccase from Saccharomyces cerevisiae. J Food Sci. 2020 Apr;85(4):1353-1360. doi: 10.1111/1750-3841.15106. Epub 2020 Mar 27. PMID: 32220140. 9: Schabo DC, Martins LM, Maciel JF, Iamanaka BT, Taniwaki MH, Schaffner DW, Magnani M. Production of aflatoxin B1 and B2 by Aspergillus flavus in inoculated wheat using typical craft beer malting conditions. Food Microbiol. 2020 Aug;89:103456. doi: 10.1016/j.fm.2020.103456. Epub 2020 Feb 8. PMID: 32139000. 10: Pok PS, García Londoño VA, Vicente S, Romero SM, Pacín A, Tolaba M, Alzamora SM, Resnik SL. Evaluation of citrus flavonoids against Aspergillus parasiticus in maize: Aflatoxins reduction and ultrastructure alterations. Food Chem. 2020 Jul 15;318:126414. doi: 10.1016/j.foodchem.2020.126414. Epub 2020 Feb 14. PMID: 32135419. 11: Liu H, Zhao Y, Lu A, Ye J, Wang J, Wang S, Luan Y. An aptamer affinity column for purification and enrichment of aflatoxin B1 and aflatoxin B2 in agro-products. Anal Bioanal Chem. 2020 Feb;412(4):895-904. doi: 10.1007/s00216-019-02300-4. Epub 2020 Jan 3. PMID: 31900533. 12: Tezerji NS, Foroughi MM, Bezenjani RR, Jandaghi N, Rezaeipour E, Rezvani F. A facile one-pot green synthesis of β-cyclodextrin decorated porous graphene nanohybrid as a highly efficient adsorbent for extracting aflatoxins from maize and animal feeds. Food Chem. 2020 May 1;311:125747. doi: 10.1016/j.foodchem.2019.125747. Epub 2019 Oct 21. PMID: 31864190. 13: Akinola SA, Ateba CN, Mwanza M. Polyphasic Assessment of Aflatoxin Production Potential in Selected Aspergilli. Toxins (Basel). 2019 Nov 26;11(12):692. doi: 10.3390/toxins11120692. PMID: 31779084; PMCID: PMC6950480. 14: Pallarés N, Carballo D, Ferrer E, Fernández-Franzón M, Berrada H. Mycotoxin Dietary Exposure Assessment through Fruit Juices Consumption in Children and Adult Population. Toxins (Basel). 2019 Nov 22;11(12):684. doi: 10.3390/toxins11120684. PMID: 31766649; PMCID: PMC6950291. 15: Çavuşoğlu K, Yalçin E. Antioxidant-oxidant balance and vital parameter alterations in an eukaryotic system induced by aflatoxin B2 exposure. Environ Sci Pollut Res Int. 2019 Dec;26(36):37275-37281. doi: 10.1007/s11356-019-06860-x. Epub 2019 Nov 20. PMID: 31748996. 16: Al-Zoreky NS, Saleh FA. Limited survey on aflatoxin contamination in rice. Saudi J Biol Sci. 2019 Feb;26(2):225-231. doi: 10.1016/j.sjbs.2017.05.010. Epub 2017 May 20. PMID: 31485158; PMCID: PMC6717087. 17: Ren X, Zhang Q, Wu W, Yan T, Tang X, Zhang W, Yu L, Li P. Anti-idiotypic nanobody-phage display-mediated real-time immuno-PCR for sensitive, simultaneous and quantitative detection of total aflatoxins and zearalenone in grains. Food Chem. 2019 Nov 1;297:124912. doi: 10.1016/j.foodchem.2019.05.186. Epub 2019 May 28. PMID: 31253263. 18: Li Z, Tang X, Shen Z, Yang K, Zhao L, Li Y. Comprehensive comparison of multiple quantitative near-infrared spectroscopy models for Aspergillus flavus contamination detection in peanut. J Sci Food Agric. 2019 Oct;99(13):5671-5679. doi: 10.1002/jsfa.9828. Epub 2019 Jul 10. PMID: 31150109. 19: Wang Z , Zu L . Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2. Chem Commun (Camb). 2019 Apr 25;55(35):5171-5174. doi: 10.1039/c9cc01833f. PMID: 30984932. 20: Lien KW, Wang X, Pan MH, Ling MP. Assessing Aflatoxin Exposure Risk from Peanuts and Peanut Products Imported to Taiwan. Toxins (Basel). 2019 Feb 1;11(2):80. doi: 10.3390/toxins11020080. PMID: 30717134; PMCID: PMC6409992.