Synonym
Thenyldiamine HCl; CCRIS1967; CCRIS-1967; CCRIS 1967
IUPAC/Chemical Name
1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-N'-(3-thienylmethyl)-, monohydrochloride
InChi Key
OQWLDKFPOJCKBX-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H19N3S.ClH/c1-16(2)8-9-17(11-13-6-10-18-12-13)14-5-3-4-7-15-14;/h3-7,10,12H,8-9,11H2,1-2H3;1H
SMILES Code
CN(C)CCN(C1=NC=CC=C1)CC2=CSC=C2.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
297.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cerniglia CE, Hansen EB Jr, Lambert KJ, Korfmacher WA, Miller DW. Fungal transformations of antihistamines: metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives. Xenobiotica. 1988 Mar;18(3):301-12. doi: 10.3109/00498258809041666. PMID: 2898181.
2: Thompson HC Jr, Holder CL, Althaus JR. Trace determination of the antihistamines tripelennamine hydrochloride, thenyldiamine hydrochloride, and chlorothen citrate in admixture in animal feed, human urine, and wastewater by high-pressure liquid chromatography and use of a fluorescence detector. Talanta. 1983 Apr;30(4):251-60. doi: 10.1016/0039-9140(83)80058-7. PMID: 18963353.
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6: Attwood D, Udeala OK. Aggregation of antihistamines in aqueous solution: effect of counterions on self-association of pyridine derivatives. J Pharm Sci. 1976 Jul;65(7):1053-7. doi: 10.1002/jps.2600650724. PMID: 8628.
7: Budroe JD, Shaddock JG, Casciano DA. A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay. Mutat Res. 1984 Feb;135(2):131-7. doi: 10.1016/0165-1218(84)90166-6. PMID: 6141525.
8: Freedman BJ, Meisner P, Hill GB. A comparison of the actions of different bronchodilators in asthma. Thorax. 1968 Nov;23(6):590-7. doi: 10.1136/thx.23.6.590. PMID: 4388005; PMCID: PMC471859.
9: Hernandez L, Allen PT, Poirier LA, Lijinsky W. S-adenosylmethionine, S-adenosylhomocysteine and DNA methylation levels in the liver of rats fed methapyrilene and analogs. Carcinogenesis. 1989 Mar;10(3):557-62. doi: 10.1093/carcin/10.3.557. PMID: 2924400.
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