Desvenlafaxine fumarate | CAS# 93414-04-1 (fumarate) | serotonin-norepinephrine reuptake inhibitor

MedKoo Cat#: 413584 | Name: Desvenlafaxine fumarate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desvenlafaxine fumarate is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

Chemical Structure

Desvenlafaxine fumarate

CAS#93414-04-1 (fumarate)

Theoretical Analysis

MedKoo Cat#: 413584

Name: Desvenlafaxine fumarate

CAS#: 93414-04-1 (fumarate)

Chemical Formula: C20H29NO6

Exact Mass: 0.0000

Molecular Weight: 379.45

Elemental Analysis: C, 63.31; H, 7.70; N, 3.69; O, 25.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

93413-62-8 (free base) 448904-47-0 (succinate) 386750-22-7 (succinate hydrate) 300827-87-6 (HCl) 93414-04-1 (fumarate) 1147940-37-1 (benzoate)

Synonym

Desvenlafaxine fumarate; O-Desmethylvenlafaxine fumarate

IUPAC/Chemical Name

Phenol, 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)-, (2E)-2-butenedioate (1:1) (salt)

InChi Key

SQTJDJZCPOSWSC-WLHGVMLRSA-N

InChi Code

InChI=1S/C16H25NO2.C4H4O4/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;5-3(6)1-2-4(7)8/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

SMILES Code

CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2.OC(=O)\C=C\C(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 379.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Naseeruddin R, Rosani A, Marwaha R. Desvenlafaxine. 2020 Nov 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30521250. 2: Weihs KL, Murphy W, Abbas R, Chiles D, England RD, Ramaker S, Wajsbrot DB. Desvenlafaxine Versus Placebo in a Fluoxetine-Referenced Study of Children and Adolescents with Major Depressive Disorder. J Child Adolesc Psychopharmacol. 2018 Feb;28(1):36-46. doi: 10.1089/cap.2017.0100. Epub 2017 Nov 30. PMID: 29189044; PMCID: PMC5771543. 3: Alcantara-Montero A. Desvenlafaxina y dolor neuropatico: beneficios clinicos adicionales de un inhibidor de la recaptacion de serotonina-noradrenalina de segunda generacion [Desvenlafaxine and neuropathic pain: additional clinical benefits of a second generation serotonin-noradrenaline reuptake inhibitor]. Rev Neurol. 2017 Mar 1;64(5):219-226. Spanish. PMID: 28229443. 4: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Desvenlafaxine. 2020 Oct 19. PMID: 30000652. 5: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Venlafaxine, Desvenlafaxine. 2020 Mar 6. PMID: 31644106. 6: Poitras V, Visintini S. Desvenlafaxine versus Venlafaxine for the Treatment of Adult Patients with Major Depressive Disorder: A Review of the Comparative Clinical and Cost-Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Oct 25. PMID: 29889482. 7: Yang LP, Plosker GL. Desvenlafaxine extended release. CNS Drugs. 2008;22(12):1061-9. doi: 10.2165/0023210-200822120-00008. PMID: 18998743. 8: Low Y, Setia S, Lima G. Drug-drug interactions involving antidepressants: focus on desvenlafaxine. Neuropsychiatr Dis Treat. 2018 Feb 19;14:567-580. doi: 10.2147/NDT.S157708. PMID: 29497300; PMCID: PMC5822840. 9: Laoutidis ZG, Kioulos KT. Desvenlafaxine for the acute treatment of depression: a systematic review and meta-analysis. Pharmacopsychiatry. 2015 Sep;48(6):187-99. doi: 10.1055/s-0035-1555879. Epub 2015 Jul 23. PMID: 26205685. 10: Sproule BA, Hazra M, Pollock BG. Desvenlafaxine succinate for major depressive disorder. Drugs Today (Barc). 2008 Jul;44(7):475-87. doi: 10.1358/dot.2008.44.7.1227147. PMID: 18806899.