MedKoo Cat#: 413559 | Name: Desaspidin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desaspidin is an anthelmintic. Desapidin may occur in natural form within some plants such as Coastal woodfern, Dryopteris arguta. Since the 1950s the inhibition effects of desapidins upon phosphorylation in chloroplasts has been noted and studied.

Chemical Structure

Desaspidin
Desaspidin
CAS#114-43-2

Theoretical Analysis

MedKoo Cat#: 413559

Name: Desaspidin

CAS#: 114-43-2

Chemical Formula: C24H30O8

Exact Mass: 446.1941

Molecular Weight: 446.49

Elemental Analysis: C, 64.56; H, 6.77; O, 28.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Desaspidin; Desaspidin BB; Rosapin;
IUPAC/Chemical Name
2,5-Cyclohexadien-1-one, 2-((2,4-dihydroxy-6-methoxy-3-(1-oxobutyl)phenyl)methyl)-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)-
InChi Key
GAHOBHHMYUYJDT-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H30O8/c1-6-8-14(25)18-16(27)11-17(32-5)12(20(18)28)10-13-21(29)19(15(26)9-7-2)23(31)24(3,4)22(13)30/h11,27-28,30-31H,6-10H2,1-5H3
SMILES Code
O=C1C(CC2=C(OC)C=C(O)C(C(CCC)=O)=C2O)=C(O)C(C)(C)C(O)=C1C(CCC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 446.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gromet-Elhanan Z, Arnon DI. Effect of desaspidin on photosynthetic phosphorylation. Plant Physiol. 1965 Nov;40(6):1060-5. doi: 10.1104/pp.40.6.1060. PMID: 5842695; PMCID: PMC550434. 2: Everson RG, Cockburn W, Ellyard PW, Gibbs M. Desaspidin and CO(2) Fixation by Spinach Chloroplasts. Plant Physiol. 1966 Sep;41(7):1240-1. doi: 10.1104/pp.41.7.1240. PMID: 16656390; PMCID: PMC550505. 3: Gromet-Elhanan Z, Avron M. Desaspidin: a nonspecific uncoupler of photophosphorylation. Plant Physiol. 1966 Sep;41(7):1231-6. doi: 10.1104/pp.41.7.1231. PMID: 16656388; PMCID: PMC550503. 4: OSTLING G. [Desaspidin as a tapeworm drug]. Nord Med. 1962 Apr 5;67:443-6. Swedish. PMID: 14482605. 5: Hind G. Photo-oxidation of desaspidin sensitized by chlorophyll. Plant Physiol. 1966 Sep;41(7):1237-9. doi: 10.1104/pp.41.7.1237. PMID: 16656389; PMCID: PMC550504. 6: Kapadia GJ, Tokuda H, Konoshima T, Takasaki M, Takayasu J, Nishino H. Anti- tumor promoting activity of Dryopteris phlorophenone derivatives. Cancer Lett. 1996 Aug 2;105(2):161-5. doi: 10.1016/0304-3835(96)04275-9. PMID: 8697439. 7: OSTLING G. Treatment of tapeworm infection with desaspidin, a new phloroglucinol derivative isolated from Finnish fern. Am J Trop Med Hyg. 1961 Nov;10:855-8. PMID: 14482604. 8: Tsujimoto HY, McSwain BD, Arnon DI. Differential effects of desaspidin on photosynthetic phosphorylation. Plant Physiol. 1966 Oct;41(8):1376-80. doi: 10.1104/pp.41.8.1376. PMID: 5978550; PMCID: PMC550534. 9: Runeberg L. Titration of mitochondrial adenosinetriphosphatase with desaspidin. Biochem Biophys Res Commun. 1964;14:58-63. doi: 10.1016/0006-291x(63)90211-0. PMID: 4220837. 10: Palva IP, Rantanen I, Salmenperä A. Expulsion of the fish tapeworm using aspidin and desaspidin. Ann Med Intern Fenn. 1965;54(3):137-8. PMID: 5892556.