GDC-0310 is a selective Nav1.7 inhibitor (EC50,u of 3.5 nM). GDC-0310 showed improved permeability inMDCK cells and increased kinetic solubility. GDC-0310 showed substantially improved Nav selectivity and ADME properties.
MedKoo Cat#: 464277
Name: GDC-0310
CAS#: 1788063-52-4
Chemical Formula: C25H29Cl2FN2O4S
Exact Mass: 542.1209
Molecular Weight: 543.48
Elemental Analysis: C, 55.25; H, 5.38; Cl, 13.05; F, 3.50; N, 5.15; O, 11.78; S, 5.90
The following data is based on the product molecular weight 543.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
