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MedKoo Cat#: 464271 | Name: Ticlopidine-d4 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ticlopidine-d4 is intended for use as an internal standard for the quantification of ticlopidine by GC- or LC-MS. Ticlopidine is a thienopyridine P2Y12 receptor antagonist. It inhibits aggregation of human platelets induced by collagen, arachidonic acid, and ADP (IC50s = 75, 600, and 1,300 μM, respectively). It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg. Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats. Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.

Chemical Structure

Ticlopidine-d4 HCl
Ticlopidine-d4 HCl
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464271

Name: Ticlopidine-d4 HCl

CAS#: unknown

Chemical Formula: C14H11D4Cl2NS

Exact Mass: 303.0553

Molecular Weight: 304.27

Elemental Analysis: C, 55.27; H, 6.29; Cl, 23.30; N, 4.60; S, 10.54

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
5mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Ticlopidine-d4 HCl; Ticlopidine d4 HCl; Ticlopidine-d4 hydrochloride; Ticlopidine d4 hydrochloride;
IUPAC/Chemical Name
5-(chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
InChi Key
MTKNGOHFNXIVOS-FOMJDCLLSA-N
InChi Code
InChI=1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14;/h1-4,6,8H,5,7,9-10H2;1H/i1D,2D,3D,4D;
SMILES Code
ClC1=C(CN2CC3=C(CC2)SC=C3)C([2H])=C([2H])C([2H])=C1[2H].Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 304.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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JAMA. 2021 Mar 2;325(9):890. doi: 10.1001/jama.2020.26020. PMID: 33651086. 5: Song L, Xu DY, Zhou P, Liu C, Sheng ZX, Li JN, Zhou JY, Chen RZ, Chen Y, Zhao HJ, Yan HB. [The variation of serum uric acid levels among patients with myocardial infarction treated with ticagrelor and the association between serum uric acid and platelet reactivity]. Zhonghua Xin Xue Guan Bing Za Zhi. 2021 Feb 24;49(2):170-175. Chinese. doi: 10.3760/cma.j.cn112148-20200509-00383. PMID: 33611904. 6: Shi GX, Zhao ZH, Yang XY, Lin M, Chen ZX. Correlation study of CYP2C19 gene polymorphism and clopidogrel resistance in Han Chinese patients with cerebral infarction in Guizhou region. Medicine (Baltimore). 2021 Feb 12;100(6):e24481. doi: 10.1097/MD.0000000000024481. PMID: 33578542; PMCID: PMC7886463. 7: Shi W, Yan L, Yang J, Yu M. Ethnic variance on long term clinical outcomes of concomitant use of proton pump inhibitors and clopidogrel in patients with stent implantation: A PRISMA-complaint systematic review with meta-analysis. Medicine (Baltimore). 2021 Feb 12;100(6):e24366. doi: 10.1097/MD.0000000000024366. PMID: 33578533; PMCID: PMC7886473. 8: Sikharulidze I, Chelidze K, Mamatsashvili I. CARDIOVASCULAR EVENT ASSESSMENT IN PATIENTS WITH NONOBSTRUCTIVE CORONARY ARTERY DISEASE UNDERGOING DUAL ANTIPLATELET TREATMENT. Georgian Med News. 2020 Dec;(309):43-46. PMID: 33526728. 9: Moreno R. After TAVI, aspirin vs. aspirin + clopidogrel for 3 mo reduced bleeding and a composite of bleeding and thrombotic events at 1 y. Ann Intern Med. 2021 Feb;174(2):JC21. doi: 10.7326/ACPJ202102160-021. Epub 2021 Feb 2. PMID: 33524286. 10: Wang W, Wang B, Chen Y, Wei S. Late Stent Thrombosis After Drug-Coated Balloon Coronary Angioplasty for In-Stent Restenosis. Int Heart J. 2021 Jan 30;62(1):171-174. doi: 10.1536/ihj.20-309. Epub 2021 Jan 16. PMID: 33455983. 11: Corbett SJ, Ftouh S, Lewis S, Lovibond K; Guideline Committee. Acute coronary syndromes: summary of updated NICE guidance. BMJ. 2021 Jan 15;372:m4760. doi: 10.1136/bmj.m4760. PMID: 33452009. 12: Guo S, Lin Y, Ma X, Zhao Y, Jin A, Liu X, Sun L, Meng G. Long-Term Safety and Efficacy of Antiplatelet Therapy in Patients With Cerebral Infarction With Thrombocytopenia. Clin Appl Thromb Hemost. 2021 Jan-Dec;27:1076029620980067. doi: 10.1177/1076029620980067. PMID: 33443453; PMCID: PMC7812396. 13: Wiśniewski A. Multifactorial Background for a Low Biological Response to Antiplatelet Agents Used in Stroke Prevention. Medicina (Kaunas). 2021 Jan 10;57(1):59. doi: 10.3390/medicina57010059. PMID: 33435185; PMCID: PMC7827369. 14: Fahrni G, Jeger R, Mueller C. Single or Dual Antiplatelet Treatment after TAVI. N Engl J Med. 2021 Jan 7;384(1):90. doi: 10.1056/NEJMc2032808. PMID: 33406347. 15: Eikelboom R, Belley-Côté EP, Whitlock RP. Single or Dual Antiplatelet Treatment after TAVI. N Engl J Med. 2021 Jan 7;384(1):90. doi: 10.1056/NEJMc2032808. PMID: 33406346. 16: Anwar S, Spence E, Zawadka M. Single or Dual Antiplatelet Treatment after TAVI. N Engl J Med. 2021 Jan 7;384(1):89-90. doi: 10.1056/NEJMc2032808. PMID: 33406345. 17: Mahtta D, Lee MT, Ramsey DJ, Akeroyd JM, Krittanawong C, Khan SU, Sinh P, Alam M, Garratt KN, Schofield RS, Ballantyne CM, Petersen LA, Virani SS. Significant Facility-Level Variation in Utilization of and Adherence with Secondary Prevention Therapies Among Patients with Premature Atherosclerotic Cardiovascular Disease: Insights from the VITAL (Veterans wIth premaTure AtheroscLerosis) Registry7. Cardiovasc Drugs Ther. 2021 Jan 5. doi: 10.1007/s10557-020-07125-3. Epub ahead of print. PMID: 33400053. 18: Yang CC, Gu WJ, Lyu ZH, Cheng Y, Jia AH, Dou JT, Ba JM, Mu YM. [One case report of insulin autoimmune syndrome induced by clopidogrel]. Zhonghua Nei Ke Za Zhi. 2021 Jan 1;60(1):55-57. Chinese. doi: 10.3760/cma.j.cn112138-20200221-00109. PMID: 33397023. 19: Woo HG, Lee HA, Ryu DR, Song TJ. Association of Mortality with Antiplatelet Treatment in Patients with Stent Placement or Angioplasty: A Population-Based Nested Case-Control Study. Yonsei Med J. 2021 Jan;62(1):75-85. doi: 10.3349/ymj.2021.62.1.75. PMID: 33381937; PMCID: PMC7820450. 20: Joob B, Wiwanitkit V. CYP2C19*2 polymorphism and clopidogrel resistance. Arch Cardiol Mex. 2020;90(4):544. English. doi: 10.24875/ACM.20000396. PMID: 33373355.