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MedKoo Cat#: 526272 | Name: TIBI

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TIBI is a potent ATP-competitive dual inhibitor of Rio1 and CK2.

Chemical Structure

TIBI
TIBI
CAS#1196457-06-3

Theoretical Analysis

MedKoo Cat#: 526272

Name: TIBI

CAS#: 1196457-06-3

Chemical Formula: C7H2I4N2

Exact Mass: 621.6397

Molecular Weight: 621.72

Elemental Analysis: C, 13.52; H, 0.32; I, 81.65; N, 4.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TIBI
IUPAC/Chemical Name
4,5,6,7-Tetraiodobenzimidazole
InChi Key
ZUHFPYANLLWSJR-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H2I4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)
SMILES Code
IC1=C2C(N=CN2)=C(I)C(I)=C1I
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 621.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tibi L, van Oppen P, van Balkom AJLM, Eikelenboom M, Rickelt J, Schruers KRJ, Anholt GE. The long-term association of OCD and depression and its moderators: A four-year follow up study in a large clinical sample. Eur Psychiatry. 2017 Apr 7;44:76-82. doi: 10.1016/j.eurpsy.2017.03.009. [Epub ahead of print] PubMed PMID: 28545012. 2: Buckert D, Cieslik M, Tibi R, Radermacher M, Rottbauer W, Bernhardt P. Cardiac magnetic resonance imaging derived quantification of myocardial ischemia and scar improves risk stratification and patient management in stable coronary artery disease. Cardiol J. 2017 Mar 29. doi: 10.5603/CJ.a2017.0036. [Epub ahead of print] PubMed PMID: 28353309. 3: Jurj A, Tomuleasa C, Tat TT, Berindan-Neagoe I, Vesa SV, Ionescu DC. Antiproliferative and Apoptotic Effects of Lidocaine on Human Hepatocarcinoma Cells. A preliminary study. J Gastrointestin Liver Dis. 2017 Mar;26(1):45-50. doi: 10.15403/jgld.2014.1121.261.juj. PubMed PMID: 28338113. 4: Shao Z, Al Tibi M, Wakim-Fleming J. Update on viral hepatitis in pregnancy. Cleve Clin J Med. 2017 Mar;84(3):202-206. doi: 10.3949/ccjm.84a.15139. Review. PubMed PMID: 28322675. 5: Haider R, Regnier P, Roustan FR, Séverac F, Treacy PJ, Mendel L, Bodokh Y, Tibi B, Prader R, Traxer O, Chevallier D, Amiel J, Durand M. [Percutaneous nephrolithotomy for kidney stones in elderly patients: Meta-analysis of results and complications]. Prog Urol. 2017 Feb;27(2):58-67. doi: 10.1016/j.purol.2016.12.008. Epub 2017 Feb 4. French. PubMed PMID: 28169121. 6: Ursu R, Carpentier A, Metellus P, Lubrano V, Laigle-Donadey F, Capelle L, Guyotat J, Langlois O, Bauchet L, Desseaux K, Tibi A, Chinot O, Lambert J, Carpentier AF. Intracerebral injection of CpG oligonucleotide for patients with de novo glioblastoma-A phase II multicentric, randomised study. Eur J Cancer. 2017 Mar;73:30-37. doi: 10.1016/j.ejca.2016.12.003. Epub 2017 Jan 28. PubMed PMID: 28142059. 7: Aaron S, Mani S, Prabhakar AT, Babu PS, Kumar S, Benjamin RN, Sivadasan A, Muthusamy K, Patil AK, Mathew V, Alexander M. Sonothrombolysis for acute ischemic stroke - Break on through to the other side. Neurol India. 2017 Jan-Feb;65(1):52-57. doi: 10.4103/0028-3886.198213. PubMed PMID: 28084238. 8: Kubiński K, Masłyk M, Orzeszko A. Benzimidazole inhibitors of protein kinase CK2 potently inhibit the activity of atypical protein kinase Rio1. Mol Cell Biochem. 2017 Feb;426(1-2):195-203. doi: 10.1007/s11010-016-2892-x. Epub 2016 Dec 1. PubMed PMID: 27909846; PubMed Central PMCID: PMC5290066. 9: Sobrino-Garcia P, Garcia-Pastor A, Garcia-Arratibel A, Dominguez-Rubio R, Rodriguez-Cruz PM, Iglesias-Mohedano AM, Diaz-Otero F, Vazquez-Alen P, Fernandez-Bullido Y, Villanueva-Osorio JA, Gil-Nunez A. [Diagnostic, prognostic and therapeutic implications of transcranial color-coded duplex sonography in acute ischemic stroke: TIBI and COGIF scores validation]. Rev Neurol. 2016 Oct 16;63(8):351-357. Spanish. PubMed PMID: 27699751. 10: Hassan NE, Tibi PR, Marques MB. Society for the Advancement of Patient Blood Management and Anesthesia & Analgesia: A New Collaboration and Home for Blood Management Research. Anesth Analg. 2016 Oct;123(4):816-7. doi: 10.1213/ANE.0000000000001583. PubMed PMID: 27636571. 11: Caruba T, Hourton D, Sabatier B, Rousseau D, Tibi A, Hoffart-Jourdain C, Souag A, Freitas N, Yjjou M, Almeida C, Gomes N, Aucouturier P, Djadi-Prat J, Menasché P, Chatellier G, Cholley B. Rationale and design of the multicenter randomized trial investigating the effects of levosimendan pretreatment in patients with low ejection fraction (≤40 %) undergoing CABG with cardiopulmonary bypass (LICORN study). J Cardiothorac Surg. 2016 Aug 5;11(1):127. doi: 10.1186/s13019-016-0530-z. PubMed PMID: 27496105; PubMed Central PMCID: PMC4974786. 12: Gupta D, Sharma A, Uchino K, Alexandrov AV, Khan K, Shuaib A, Saqqur M. Accuracy of National Institutes of Health Stroke Scale Score in Predicting the Site of Arterial Occlusion in Acute Stroke: A Transcranial Doppler Study. J Stroke Cerebrovasc Dis. 2016 Sep;25(9):2109-15. doi: 10.1016/j.jstrokecerebrovasdis.2016.06.004. Epub 2016 Jul 25. PubMed PMID: 27468661. 13: Jacq L, Vallet-Anfosso A, Tibi T, Genillier PL, Petit B, Desse D, Franke F, Bellemain-Appaix A, Rafidiniaina D, Bernasconi F. [Cardiovascular events during the severe weather affecting the French Riviera on 3 October 2015]. Ann Cardiol Angeiol (Paris). 2016 Nov;65(5):373-374. doi: 10.1016/j.ancard.2016.06.002. Epub 2016 Jul 20. French. PubMed PMID: 27449736. 14: Traboulsi EI, Vanderveen D, Morrison D, Drews-Botsch CD, Lambert SR; Infant Aphakia Treatment Study Group. Associated systemic and ocular disorders in patients with congenital unilateral cataracts: the Infant Aphakia Treatment Study experience. Eye (Lond). 2016 Sep;30(9):1170-4. doi: 10.1038/eye.2016.124. Epub 2016 Jun 17. PubMed PMID: 27315350; PubMed Central PMCID: PMC5023799. 15: Rickelt J, Viechtbauer W, Lieverse R, Overbeek T, van Balkom AJ, van Oppen P, van den Heuvel OA, Marcelis M, Eikelenboom M, Tibi L, Schruers KR. The relation between depressive and obsessive-compulsive symptoms in obsessive-compulsive disorder: Results from a large, naturalistic follow-up study. J Affect Disord. 2016 Oct;203:241-7. doi: 10.1016/j.jad.2016.06.009. Epub 2016 Jun 6. PubMed PMID: 27310102. 16: Saqqur M, Ghrooda E, Ahmad A, Khan K, Hussain MS, Shuaib A. The Combination of Clinical Features, Transcranial Doppler, and Alberta Stroke Program Early Computed Tomography Score (Computed Tomography Angiography) in Predicting Outcome in Intravenous Recombinant Tissue Plasminogen Activator-Treated Patients. J Stroke Cerebrovasc Dis. 2016 Aug;25(8):2019-23. doi: 10.1016/j.jstrokecerebrovasdis.2015.12.013. Epub 2016 May 27. PubMed PMID: 27241578. 17: Meier-Girard D, Tibi A, Abdoul H, Prot-Labarthe S, Brion F, Bourdon O, Alberti C. Academic pediatric clinical research: factors associated with study implementation duration. BMC Med Res Methodol. 2016 Mar 29;16:36. doi: 10.1186/s12874-016-0138-y. PubMed PMID: 27025840; PubMed Central PMCID: PMC4812626. 18: Baud O, Maury L, Lebail F, Ramful D, El Moussawi F, Nicaise C, Zupan-Simunek V, Coursol A, Beuchée A, Bolot P, Andrini P, Mohamed D, Alberti C; PREMILOC trial study group. Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial. Lancet. 2016 Apr 30;387(10030):1827-36. doi: 10.1016/S0140-6736(16)00202-6. Epub 2016 Feb 23. PubMed PMID: 26916176. 19: Tibi B, Vincens E, Durand M, Salet-Lizet D, Gadonneix P, Kane A, Carpentier X, Marsaud A, Rouscoff Y, Chevallier D, Amiel J, Villet R. [Not Available]. Prog Urol. 2015 Nov;25(13):843. doi: 10.1016/j.purol.2015.08.255. French. PubMed PMID: 26544450. 20: Colomb F, Andolfi C, Tibi B, Loeffler J, Durand M. [Not Available]. Prog Urol. 2015 Nov;25(13):786. doi: 10.1016/j.purol.2015.08.140. French. PubMed PMID: 26544336.

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