Helicid is a β-allopyranoside originally isolated from Helicia erratica that has diverse biological activities. It reverses decreases in serum corticosterone (CORT) levels and the expression of the serotonin (5-HT) receptor subtype 5-HT1A in rat hippocampus in a model of chronic unpredictable mild stress-induced depression when administered at a dose of 32 mg/kg per day. It also reverses stress-induced decreases in sucrose preference and immobility time in the forced swim test, indicating antidepressant-like activity, as well as decreases in locomotor activity, in the same model. Helicid increases the expression of the serotonin transporter (SERT) and reduces escape latency in the Morris water maze in a rat model of chronic unpredictable mild stress. It increases the mechanical allodynia threshold and increases non-rapid eye movement (NREM) sleep time in a manner dependent on the time-of-day of administration in a mouse model of partial sciatic nerve ligation.
MedKoo Cat#: 464269
Name: Helicid
CAS#: 80154-34-3
Chemical Formula: C13H16O7
Exact Mass: 284.0896
Molecular Weight: 284.26
Elemental Analysis: C, 54.93; H, 5.67; O, 39.40
The following data is based on the product molecular weight 284.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
