MedKoo Cat#: 463621 | Name: M351-056
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

M351-056 is a novel VISTA (V-domain immunoglobulin suppressor of T-cell activation) agonist.

Chemical Structure

M351-056
M351-056
CAS#1189495-81-5

Theoretical Analysis

MedKoo Cat#: 463621

Name: M351-056

CAS#: 1189495-81-5

Chemical Formula: C15H12BrFN2O2S3

Exact Mass: 445.9228

Molecular Weight: 447.36

Elemental Analysis: C, 40.27; H, 2.70; Br, 17.86; F, 4.25; N, 6.26; O, 7.15; S, 21.50

Price and Availability

Size Price Availability Quantity
25mg USD 750.00 2 Weeks
50mg USD 1,250.00 2 Weeks
100mg USD 2,150.00 2 Weeks
1g USD 4,650.00 2 Weeks
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Related CAS #
No Data
Synonym
M351-056; M351056; M351 056; M351-0056
IUPAC/Chemical Name
N-(4-bromo-2-fluorophenyl)-2-methyl-5-(2-methylthiazol-4-yl)thiophene-3-sulfonamide
InChi Key
VWQLSIBNGFNHPL-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H12BrFN2O2S3/c1-8-15(6-14(23-8)13-7-22-9(2)18-13)24(20,21)19-12-4-3-10(16)5-11(12)17/h3-7,19H,1-2H3
SMILES Code
O=S(C1=C(C)SC(C2=CSC(C)=N2)=C1)(NC3=CC=C(Br)C=C3F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 447.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang L, Zhang T, Wang P, Chen W, Liu W, He X, Zhang Y, Jin S, Luo Z, Zhang Z, Wang X, Liu J. Imatinib and M351-0056 enhance the function of VISTA and ameliorate the development of SLE via IFN-I and noncanonical NF-κB pathway. Cell Biol Toxicol. 2023 Dec;39(6):3287-3304. doi: 10.1007/s10565-023-09833-6. Epub 2023 Oct 7. PMID: 37804401. 2: Hu X, Qie C, Jiang J, Xie X, Chen W, Liu W, Liu J. M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA. Br J Pharmacol. 2021 Mar;178(6):1445-1458. doi: 10.1111/bph.15357. Epub 2021 Feb 20. PMID: 33450048; PMCID: PMC9328666.