Synonym
HBS-101; HBS 101; HBS101; Pitolisant; Tiprolisant
IUPAC/Chemical Name
1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine
InChi Key
NNACHAUCXXVJSP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2
SMILES Code
Clc1ccc(CCCOCCCN2CCCCC2)cc1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
295.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bolin K, Niska PÅ, Pirhonen L, Wasling P, Landtblom AM. The cost-utility of pitolisant as narcolepsy treatment. Acta Neurol Scand. 2019 Dec 14. doi: 10.1111/ane.13202. [Epub ahead of print] PubMed PMID: 31838740.
2: Setnik B, McDonnell M, Mills C, Scart-Grès C, Robert P, Dayno JM, Schwartz JC. Evaluation of the abuse potential of pitolisant, a selective H3-receptor antagonist/inverse agonist, for the treatment of adult patients with narcolepsy with or without cataplexy. Sleep. 2019 Oct 18. pii: zsz252. doi: 10.1093/sleep/zsz252. [Epub ahead of print] PubMed PMID: 31626696.
3: Dauvilliers Y, Arnulf I, Szakacs Z, Leu-Semenescu S, Lecomte I, Scart-Gres C, Lecomte JM, Schwartz JC; HARMONY III study group . Long-term use of pitolisant to treat patients with narcolepsy: Harmony III Study. Sleep. 2019 Oct 21;42(11). pii: zsz174. doi: 10.1093/sleep/zsz174. PubMed PMID: 31529094; PubMed Central PMCID: PMC6802569.
4: Fouque C, Martin R, Seguro F, Montastruc JL, de Canecaude C. Splenic Infarction in a Narcoleptic Patient Treated With Methylphenidate, Venlafaxine, and Pitolisant. Ann Pharmacother. 2019 Sep 10:1060028019872795. doi: 10.1177/1060028019872795. [Epub ahead of print] PubMed PMID: 31502855.
5: Scolnick B. Antihistamine agents and pitolisant might be useful for anorexia nervosa. Med Hypotheses. 2019 Nov;132:109342. doi: 10.1016/j.mehy.2019.109342. Epub 2019 Jul 30. PubMed PMID: 31421416.
