MedKoo Cat#: 413526 | Name: BD 1008 Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BD 1008 Free Base is a selective sigma receptor antagonist, with a reported binding affinity of Kᵢ = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor.

Chemical Structure

BD 1008 Free Base
BD 1008 Free Base
CAS#138356-08-8 (free base)

Theoretical Analysis

MedKoo Cat#: 413526

Name: BD 1008 Free Base

CAS#: 138356-08-8 (free base)

Chemical Formula: C15H22Cl2N2

Exact Mass: 300.1160

Molecular Weight: 301.26

Elemental Analysis: C, 59.80; H, 7.36; Cl, 23.53; N, 9.30

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Synonym
BD 1008 Free Base; BD1008; BD-1008
IUPAC/Chemical Name
1-Pyrrolidineethanamine, N-(2-(3,4-dichlorophenyl)ethyl)-N-methyl-
InChi Key
ASGIQUHBAVIOTI-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H22Cl2N2/c1-18(10-11-19-7-2-3-8-19)9-6-13-4-5-14(16)15(17)12-13/h4-5,12H,2-3,6-11H2,1H3
SMILES Code
CN(CCC1=CC=C(Cl)C(Cl)=C1)CCN2CCCC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 301.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Monnet FP, de Costa BR, Bowen WD. Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. Br J Pharmacol. 1996 Sep;119(1):65-72. doi: 10.1111/j.1476-5381.1996.tb15678.x. PMID: 8872358; PMCID: PMC1915737. 2: Garcés-Ramírez L, Green JL, Hiranita T, Kopajtic TA, Mereu M, Thomas AM, Mesangeau C, Narayanan S, McCurdy CR, Katz JL, Tanda G. Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis. Biol Psychiatry. 2011 Feb 1;69(3):208-17. doi: 10.1016/j.biopsych.2010.07.026. Epub 2010 Oct 15. PMID: 20950794; PMCID: PMC3015019. 3: Hiranita T, Soto PL, Tanda G, Kopajtic TA, Katz JL. Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats. J Pharmacol Exp Ther. 2013 Oct;347(1):20-9. doi: 10.1124/jpet.113.207522. Epub 2013 Aug 1. PMID: 23908387; PMCID: PMC3781409. 4: Desai RI, Grandy DK, Lupica CR, Katz JL. Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. J Pharmacol Exp Ther. 2014 Jan;348(1):106-15. doi: 10.1124/jpet.113.208538. Epub 2013 Nov 5. PMID: 24194528; PMCID: PMC3868881. 5: Hiranita T, Soto PL, Tanda G, Katz JL. Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine. J Pharmacol Exp Ther. 2010 Feb;332(2):515-24. doi: 10.1124/jpet.109.159236. Epub 2009 Nov 5. PMID: 19892920; PMCID: PMC2812106. 6: Hiranita T, Soto PL, Kohut SJ, Kopajtic T, Cao J, Newman AH, Tanda G, Katz JL. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. J Pharmacol Exp Ther. 2011 Nov;339(2):662-77. doi: 10.1124/jpet.111.185025. Epub 2011 Aug 22. PMID: 21859929; PMCID: PMC3199989. 7: Hudzik TJ, De Costa BR, McMillan DE. Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers. Eur J Pharmacol. 1993 May 19;236(2):279-87. doi: 10.1016/0014-2999(93)90599-d. PMID: 8100532. 8: Beninger RJ. International Behavioral Neuroscience Society - Ninth meeting. Neurochemistry of feeding. IDrugs. 2000 Jul;3(7):745-6. PMID: 16080042. 9: Couture S, Debonnel G. Modulation of the neuronal response to N-methyl-D- aspartate by selective sigma2 ligands. Synapse. 1998 May;29(1):62-71. doi: 10.1002/(SICI)1098-2396(199805)29:1<62::AID-SYN5>3.0.CO;2-9. PMID: 9552175. 10: Berardi F, Ferorelli S, Colabufo NA, Leopoldo M, Perrone R, Tortorella V. A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites. Bioorg Med Chem. 2001 May;9(5):1325-35. doi: 10.1016/s0968-0896(01)00011-6. PMID: 11377189.