Synonym
Desipramine Free Base; Norimipramine; Desmethylimipramine; Monodemethylimipramine; Desipramin; Demethylimipramine; Dimethylimipramine; Dezipramine; N-Desmethylimipramine; DMI;
IUPAC/Chemical Name
5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-
InChi Key
HCYAFALTSJYZDH-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
SMILES Code
CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| To be determined |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
266.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med. 1992 May 7;326(19):1250-6. doi: 10.1056/NEJM199205073261904. PMID: 1560801.
2: Branco-de-Almeida LS, Franco GCN, Castro ML, Vieira MS, Galvão-Moreira LV, Cortelli SC, Anbinder AL, Kawai T, Rosalen PL. Protective effects of desipramine on alveolar bone in experimental periodontitis. J Periodontol. 2020 Dec;91(12):1694-1703. doi: 10.1002/JPER.19-0569. Epub 2020 Jun 5. PMID: 32294250.
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7: Ghanizadeh A. A systematic review of the efficacy and safety of desipramine for treating ADHD. Curr Drug Saf. 2013 Jul;8(3):169-74. doi: 10.2174/15748863113089990029. PMID: 23914752.
8: Kishore-Kumar R, Max MB, Schafer SC, Gaughan AM, Smoller B, Gracely RH, Dubner R. Desipramine relieves postherpetic neuralgia. Clin Pharmacol Ther. 1990 Mar;47(3):305-12. doi: 10.1038/clpt.1990.33. PMID: 2178851.
9: Leonard BE. A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. Int Clin Psychopharmacol. 1987 Oct;2(4):281-97. doi: 10.1097/00004850-198710000-00001. PMID: 2891742.
10: Werry JS. The safety of desipramine. J Am Acad Child Adolesc Psychiatry. 1994 May;33(4):588-91. doi: 10.1097/00004583-199405000-00018. PMID: 8005913.
