QQN52061 | CAS# 907952-06-1 | GPR34 receptor modulator

MedKoo Cat#: 555923 | Name: QQN52061

Description:

WARNING: This product is for research use only, not for human or veterinary use.

QQN52061 is GPR34 receptor modulator, which can control function of GPR34 receptor (as antagonist or inverse agonist). QQN52061 was first reported in PCT Int. Appl. (2006), WO 2006088246. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

QQN52061

CAS# 907952-06-1

Theoretical Analysis

MedKoo Cat#: 555923

Name: QQN52061

CAS#: 907952-06-1

Chemical Formula: C31H26ClNO4

Exact Mass: 511.1550

Molecular Weight: 512.00

Elemental Analysis: C, 72.72; H, 5.12; Cl, 6.92; N, 2.74; O, 12.50

Price and Availability

Size	Price	Availability
100mg	USD 1,650.00	2 Weeks
200mg	USD 2,650.00	2 Weeks
500mg	USD 3,950.00	2 Weeks
1g	USD 4,950.00	2 Weeks
2g	USD 7,950.00	2 Weeks

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Related CAS #

No Data

Synonym

QQN52061; QQN-52061; QQN 52061;

IUPAC/Chemical Name

N-[(2E)-3-(4'-Chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)tyrosine

InChi Key

QPRREELAPZFVLQ-WDOJQBHRSA-N

InChi Code

InChI=1S/C31H26ClNO4/c32-27-15-13-26(14-16-27)25-11-6-22(7-12-25)10-19-30(34)33-29(31(35)36)20-23-8-17-28(18-9-23)37-21-24-4-2-1-3-5-24/h1-19,29H,20-21H2,(H,33,34)(H,35,36)/b19-10+/t29-/m0/s1

SMILES Code

O=C(O)[C@H](CC1=CC=C(OCC2=CC=CC=C2)C=C1)NC(/C=C/C3=CC=C(C4=CC=C(Cl)C=C4)C=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

to be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GPR34 receptor antagonist 2 (Compound D2) is a GPR34 receptor antagonist, which can be used for the study to immune diseases, inflammatory diseases, allergic diseases, respiratory diseases, urological diseases, cardiovascular diseases.

In vitro activity:

Endogenous ligands of GPR34, a G protein-coupled receptor, act on histamine-releasing activity on antigen- or concanavalin A- stimulated rat mast cells and synergize with nerve growth factor on rat mast cells. It is a lipid suchas lysophosphatidylserine havingthe activity of releasing histamine. GPR34 antagonists can be used, for example, for histamine release inhibitors, immune diseases, edema, hyperacidity, etc. Reference: Preparation of N-acyl-amino acid derivatives for controlling function of GPR34 receptor as antagonists or inverse agonists. https://patents.google.com/patent/WO2006088246A1/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	50.0	97.66

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 512.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Preparation of N-acyl-amino acid derivatives for controlling function of GPR34 receptor as antagonists or inverse agonists Quick View Other Sources By Ito, Fumio; Kimura, Eiji; Imai, Tomomi; Mori, Masaaki; Aramaki, Yoshio; Kohara, Yasuhisa; Sugo, Tsukasa; Hayase, Yoji; Kobayashi, Hiromi; Ogi, Kazuhiro From PCT Int. Appl. (2006), WO 2006088246 A1 20060824. | Language: Japanese, Database: CAPLUS

In vitro protocol:

In vivo protocol:

TBD