Lacutoclax | CAS#2291166-56-6 | Bcl-2 inhibitor

MedKoo Cat#: 140229 | Name: Lacutoclax

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lacutoclax, also known as LP-108, is an orally bioavailable Bcl-2 inhibitor ( the anti-apoptotic protein B-cell lymphoma 2), with potential pro-apoptotic and antineoplastic activities. LP-108 targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival.

Chemical Structure

Lacutoclax

CAS#2291166-56-6

Theoretical Analysis

MedKoo Cat#: 140229

Name: Lacutoclax

CAS#: 2291166-56-6

Chemical Formula: C48H55ClN8O7S

Exact Mass: 922.3603

Molecular Weight: 923.53

Elemental Analysis: C, 62.43; H, 6.00; Cl, 3.84; N, 12.13; O, 12.13; S, 3.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Lacutoclax, LP-108; LP108; LP 108;

IUPAC/Chemical Name

4-{4-[(4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}-2-[(3R)-3-methyl2,3-dihydropyrrolo[3',2':5,6]pyrido[2,3-b][1,4]oxazin1(6H)-yl]-N-(3-nitro-4-{[(oxan-4-yl)methyl]amino}benzene-1-sulfonyl)benzamide

InChi Key

CCDRQWAEZGRMTP-WJOKGBTCSA-N

InChi Code

InChI=1S/C48H55ClN8O7S/c1-31-29-56(44-24-34-13-17-50-45(34)52-47(44)64-31)42-25-37(55-20-18-54(19-21-55)30-35-12-16-48(2,3)27-40(35)33-4-6-36(49)7-5-33)8-10-39(42)46(58)53-65(61,62)38-9-11-41(43(26-38)57(59)60)51-28-32-14-22-63-23-15-32/h4-11,13,17,24-26,31-32,51H,12,14-16,18-23,27-30H2,1-3H3,(H,50,52)(H,53,58)/t31-/m1/s1

SMILES Code

O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3N7C(C=C8C(NC=C8)=N9)=C9O[C@H](C)C7

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 923.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.