Synonym
Inosine pranobex; NP113; NP-113; NP 113
IUPAC/Chemical Name
4-acetamidobenzoic acid compound with 9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one and 1-(dimethylamino)propan-2-ol (3:1:3)
InChi Key
YLDCUKJMEKGGFI-QCSRICIXSA-N
InChi Code
InChI=1S/C10H12N4O5.3C9H9NO3.3C5H13NO/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18;3*1-6(11)10-8-4-2-7(3-5-8)9(12)13;3*1-5(7)4-6(2)3/h2-4,6-7,10,15-17H,1H2,(H,11,12,18);3*2-5H,1H3,(H,10,11)(H,12,13);3*5,7H,4H2,1-3H3/t4-,6-,7-,10-;;;;;;/m1....../s1
SMILES Code
CC(CN(C)C)O.CC(CN(C)C)O.CC(CN(C)C)O.CC(Nc1ccc(C(O)=O)cc1)=O.CC(Nc2ccc(C(O)=O)cc2)=O.CC(Nc3ccc(C(O)=O)cc3)=O.OC[C@H]4O[C@@H](n5c6c(C(NC=N6)=O)nc5)[C@@H]([C@@H]4O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| To be determined |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,115.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sliva J, Pantzartzi CN, Votava M. Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases. Adv Ther. 2019 Aug;36(8):1878-1905. doi: 10.1007/s12325-019-00995-6. Epub 2019 Jun 5. PMID: 31168764; PMCID: PMC6822865.
2: Tobólska S, Terpiłowska S, Jaroszewski J, Siwicki AK. Genotoxicity and Mutagenicity of Inosine Pranobex. J Vet Res. 2018 Oct 24;62(2):207-213. doi: 10.2478/jvetres-2018-0030. PMID: 30364916; PMCID: PMC6200294.
3: Beran J, Šalapová E, Špajdel M; Isoprinosine Study (EWO ISO-2014/1) Team. Inosine pranobex is safe and effective for the treatment of subjects with confirmed acute respiratory viral infections: analysis and subgroup analysis from a Phase 4, randomised, placebo-controlled, double-blind study. BMC Infect Dis. 2016 Nov 7;16(1):648. doi: 10.1186/s12879-016-1965-5. PMID: 27821093; PMCID: PMC5100179.
4: McCarthy MT, Lin D, Soga T, Adam J, O'Callaghan CA. Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression. Eur J Immunol. 2020 Jan;50(1):130-137. doi: 10.1002/eji.201847948. Epub 2019 Sep 12. PMID: 31434164; PMCID: PMC6972573.
5: Beran J, Špajdel M, Katzerová V, Holoušová A, Malyš J, Finger Rousková J, Slíva J. Inosine Pranobex Significantly Decreased the Case-Fatality Rate among PCR Positive Elderly with SARS-CoV-2 at Three Nursing Homes in the Czech Republic. Pathogens. 2020 Dec 16;9(12):1055. doi: 10.3390/pathogens9121055. PMID: 33339426; PMCID: PMC7766462.
6: Glasky AJ, Galli M, Lassus A, Salo O. Inosine pranobex. Lancet. 1985 May 11;1(8437):1103-4. doi: 10.1016/s0140-6736(85)92408-0. PMID: 2582218.
7: De Simone C, Famularo G, Tzantzoglou S, Moretti S, Jirillo E. Inosine pranobex in the treatment of HIV infection: a review. Int J Immunopharmacol. 1991;13 Suppl 1:19-27. doi: 10.1016/0192-0561(91)90120-v. PMID: 1726683.
8: Campoli-Richards DM, Sorkin EM, Heel RC. Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1986 Nov;32(5):383-424. doi: 10.2165/00003495-198632050-00001. PMID: 2431857.
9: Inosine pranobex and mucocutaneous herpes. Lancet. 1985 Jan 26;1(8422):200-1. PMID: 2578592.
10: You Y, Wang L, Li Y, Wang Q, Cao S, Tu Y, Li S, Bai L, Lu J, Wei Z, Chen W, Hao F. Multicenter randomized study of inosine pranobex versus acyclovir in the treatment of recurrent herpes labialis and recurrent herpes genitalis in Chinese patients. J Dermatol. 2015 Jun;42(6):596-601. doi: 10.1111/1346-8138.12845. Epub 2015 Mar 26. PMID: 25819042.
