Synonym
Debrisoquine Free Base; Tendor; Debrisoquinum; Debrisoquin; Debrisoquine; Isocaramidine;
IUPAC/Chemical Name
2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
InChi Key
JWPGJSVJDAJRLW-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
SMILES Code
N=C(N1CC2=C(C=CC=C2)CC1)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| To be determined |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
175.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Idle JR, Mahgoub A, Angelo MM, Dring LG, Lancaster R, Smith RL. The metabolism of [14C]-debrisoquine in man. Br J Clin Pharmacol. 1979 Mar;7(3):257-66. doi: 10.1111/j.1365-2125.1979.tb00930.x. PMID: 371651; PMCID: PMC1429493.
2: Meyer UA, Skoda RC, Zanger UM. The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms. Pharmacol Ther. 1990;46(2):297-308. doi: 10.1016/0163-7258(90)90096-k. PMID: 2181495.
3: Lennard MS. Genetic polymorphism of sparteine/debrisoquine oxidation: a reappraisal. Pharmacol Toxicol. 1990 Oct;67(4):273-83. doi: 10.1111/j.1600-0773.1990.tb00830.x. PMID: 2077517.
4: Cooke BR, Bligh SW, Cybulski ZR, Ioannides C, Hall M. Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes. Drug Metab Dispos. 2012 Jan;40(1):70-5. doi: 10.1124/dmd.111.041566. Epub 2011 Oct 5. PMID: 21976620.
5: Spina E, Martines C, Caputi AP, Cobaleda J, Piñas B, Carrillo JA, Benitez J. Debrisoquine oxidation phenotype during neuroleptic monotherapy. Eur J Clin Pharmacol. 1991;41(5):467-70. doi: 10.1007/BF00626371. PMID: 1684751.
6: Eichelbaum M, Gross AS. The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects. Pharmacol Ther. 1990;46(3):377-94. doi: 10.1016/0163-7258(90)90025-w. PMID: 2188269.
7: Jarema M. Test hydroksylacji debryzochiny jako przykład nowych mozliwości badawczych w psychofarmakologii [Debrisoquine hydroxylation test as an example of new possibilities of research in psychopharmacology]. Psychiatr Pol. 1995 Jan-Feb;29(1):57-66. Polish. PMID: 7878155.
8: Saadatmand AR, Tadjerpisheh S, Brockmöller J, Tzvetkov MV. The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1. Biochem Pharmacol. 2012 May 15;83(10):1427-34. doi: 10.1016/j.bcp.2012.01.032. Epub 2012 Feb 10. PMID: 22342776.
9: Corado CR, McKemie DS, Knych HK. Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds. Am J Vet Res. 2016 Sep;77(9):1029-35. doi: 10.2460/ajvr.77.9.1029. PMID: 27580115.
10: Tucker GT, Silas JH, Iyun AO, Lennard MS, Smith AJ. Polymorphic hydroxylation of debrisoquine. Lancet. 1977 Oct 1;2(8040):718. doi: 10.1016/s0140-6736(77)90527-x. PMID: 71525.
