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MedKoo Cat#: 464214 | Name: FGFR4 inhibitor F-30

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FGFR4 inhibitor F-30 is a novel potent and selective FGFR4 inhibitor, covalently binding to FGFR4 protein.

Chemical Structure

FGFR4 inhibitor F-30
FGFR4 inhibitor F-30
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464214

Name: FGFR4 inhibitor F-30

CAS#: unknown

Chemical Formula: C24H21ClN4O4

Exact Mass: 464.1251

Molecular Weight: 464.91

Elemental Analysis: C, 62.00; H, 4.55; Cl, 7.63; N, 12.05; O, 13.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
FGFR4 inhibitor F-30; FGFR4 inhibitor F30; FGFR4 inhibitor F 30;
IUPAC/Chemical Name
3-(2-chloroacetamido)-N-(6-(3,5-dimethoxyphenyl)-1H-indazol-3-yl)benzamide
InChi Key
RGTPQWZZUGUUOY-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H21ClN4O4/c1-32-18-9-16(10-19(12-18)33-2)14-6-7-20-21(11-14)28-29-23(20)27-24(31)15-4-3-5-17(8-15)26-22(30)13-25/h3-12H,13H2,1-2H3,(H,26,30)(H2,27,28,29,31)
SMILES Code
O=C(NC1=NNC2=C1C=CC(C3=CC(OC)=CC(OC)=C3)=C2)C4=CC=CC(NC(CCl)=O)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 464.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen X, Liu Y, Zhang L, Chen D, Dong Z, Zhao C, Liu Z, Xia Q, Wu J, Chen Y, Zheng X, Cai Y. Design, synthesis, and biological evaluation of indazole derivatives as selective and potent FGFR4 inhibitors for the treatment of FGF19-driven hepatocellular cancer. Eur J Med Chem. 2021 Jan 29;214:113219. doi: 10.1016/j.ejmech.2021.113219. Epub ahead of print. PMID: 33618175.

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