CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1. It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1. CAY10774 increases surface expression of PD-1 on primary human CD4+ and CD8+ T cells co-cultured with aAPCs.
MedKoo Cat#: 464179
Name: CAY10774
CAS#: unknown
Chemical Formula: C26H25Br2NO3
Exact Mass: 557.0201
Molecular Weight: 559.30
Elemental Analysis: C, 55.84; H, 4.51; Br, 28.57; N, 2.50; O, 8.58
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| To be determined | 0.0 | 100.00 |
The following data is based on the product molecular weight 559.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
