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MedKoo Cat#: 413473 | Name: Thiopropazate Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thiopropazate Free Base is a typical antipsychotic of the phenothiazine class. It is a prodrug to perphenazine.

Chemical Structure

Thiopropazate Free Base
Thiopropazate Free Base
CAS# 84-06-0 (free base)

Theoretical Analysis

MedKoo Cat#: 413473

Name: Thiopropazate Free Base

CAS#: 84-06-0 (free base)

Chemical Formula: C23H28ClN3O2S

Exact Mass: 445.1591

Molecular Weight: 446.01

Elemental Analysis: C, 61.94; H, 6.33; Cl, 7.95; N, 9.42; O, 7.17; S, 7.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
146-28-1 (HCl) 84-06-0 (free base)
Synonym
Thiopropazate Free Base; HSDB3401; HSDB-3401; HSDB 3401
IUPAC/Chemical Name
1-Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-, acetate (ester) (9CI)
InChi Key
AIUHRQHVWSUTGJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H28ClN3O2S/c1-18(28)29-16-15-26-13-11-25(12-14-26)9-4-10-27-20-5-2-3-6-22(20)30-23-8-7-19(24)17-21(23)27/h2-3,5-8,17H,4,9-16H2,1H3
SMILES Code
ClC(C=C1N2CCCN3CCN(CCOC(C)=O)CC3)=CC=C1SC4=C2C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
To be determined 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 446.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bhidayasiri R, Fahn S, Weiner WJ, Gronseth GS, Sullivan KL, Zesiewicz TA; American Academy of Neurology. Evidence-based guideline: treatment of tardive syndromes: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013 Jul 30;81(5):463-9. doi: 10.1212/WNL.0b013e31829d86b6. Erratum in: Neurology. 2013 Nov 26;81(22):1968. PMID: 23897874. 2: Singer K, Cheng MN. Thiopropazate hydrochloride in persistent dyskinesia. Br Med J. 1971 Dec 4;4(5787):626. doi: 10.1136/bmj.4.5787.626-c. PMID: 5167074; PMCID: PMC1799903. 3: DARLING HF. Acetophenazine (Tindal) and thiopropazate (Dartal) in ambulatory psychoneurotic patients. Am J Psychiatry. 1961 Oct;118:358-9. doi: 10.1176/ajp.118.4.358. PMID: 13883575. 4: McLellan DL, Chalmers RJ, Johnson RH. A double-blind trial of tetrabenazine, thiopropazate, and placebo in patients with chorea. Lancet. 1974 Jan 26;1(7848):104-7. doi: 10.1016/s0140-6736(74)92338-1. PMID: 4130307. 5: DOBKIN AB, PURKIN N. The antisialogogue effect of phenothiazine derivatives: comparison of pecazine, perphenazine, fluphenazine, thiopropazate, pipamazine and triflupromazine. Br J Anaesth. 1960 Feb;32:57-9. doi: 10.1093/bja/32.2.57. PMID: 13817061. 6: SCHAUMANN W, KURBJUWEIT HG. [Modifications of various effects of thiopropazate by a central stimulant]. Arzneimittelforschung. 1961 Apr;11:343-50. German. PMID: 13747321. 7: Singer K, Cheng MN. Thiopropazate hydrochloride in persistent dyskinesia. Br Med J. 1971 Oct 2;4(5778):22-5. doi: 10.1136/bmj.4.5778.22. PMID: 4938244; PMCID: PMC1799164. 8: Kazamatsuri H, Chien C, Cole JO. Treatment of tardive dyskinesia. II. Short- term efficacy of dopamine-blocking agents haloperidol and thiopropazate. Arch Gen Psychiatry. 1972 Jul;27(1):100-3. doi: 10.1001/archpsyc.1972.01750250086012. PMID: 4555826. 9: DOBKIN AB. Potentiation of thiopentone anaesthesia. Comparison of promethazine, chlorpromazine, perphenazine, fluphenazine, thiopropazate, pipamazine and triflupromazine. Br J Anaesth. 1960 Sep;32:424-6. doi: 10.1093/bja/32.9.424. PMID: 13723253. 10: POELDINGER W. [Therapeutic experiences with thiopropazate and with a combination of thiopropazate and chlorphencyclan (Vesitan) in psychiatry]. Praxis. 1962 Jan 18;51:73-8. German. PMID: 14487367.