Synonym
Darifenacin Free Base; Emselex; UK88525; UK 88525; UK-88525; Vesigard; Enablex; darifenacine; darifenicin
IUPAC/Chemical Name
(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
InChi Key
HXGBXQDTNZMWGS-RUZDIDTESA-N
InChi Code
InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1
SMILES Code
O=C(N)C(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3CN(CCC4=CC=C(OCC5)C5=C4)CC3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| To be determined |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
426.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Darifenacin. 2017 Jul 7. PMID: 31644105.
2: Skerjanec A. The clinical pharmacokinetics of darifenacin. Clin Pharmacokinet. 2006;45(4):325-50. doi: 10.2165/00003088-200645040-00001. PMID: 16584282.
3: Seo MS, An JR, Jung HS, Kang M, Heo R, Han ET, Yang SR, Park H, Jung WK, Choi IW, Bae YM, Na SH, Park WS. Suppression of voltage-gated K+ channels by darifenacin in coronary arterial smooth muscle cells. Eur J Pharmacol. 2021 Jan 15;891:173707. doi: 10.1016/j.ejphar.2020.173707. Epub 2020 Oct 31. PMID: 33137332.
4: Croom KF, Keating GM. Darifenacin: in the treatment of overactive bladder. Drugs Aging. 2004;21(13):885-92; discussion 893-4. doi: 10.2165/00002512-200421130-00005. PMID: 15493952.
5: Haab F, Stewart L, Dwyer P. Darifenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder. Eur Urol. 2004 Apr;45(4):420-9; discussion 429. doi: 10.1016/j.eururo.2004.01.008. PMID: 15041104.
6: Steers WD. Darifenacin: Pharmacology and clinical usage. Urol Clin North Am. 2006 Nov;33(4):475-82, viii. doi: 10.1016/j.ucl.2006.06.007. PMID: 17011383.
7: Haab F. Darifenacin in the treatment of overactive bladder. Drugs Today (Barc). 2005 Jul;41(7):441-52. doi: 10.1358/dot.2005.41.7.891719. PMID: 16193097.
8: Kissane LM, Martin KD, Meyer I, Richter HE. Effect of darifenacin on fecal incontinence in women with double incontinence. Int Urogynecol J. 2020 Jun 15:10.1007/s00192-020-04369-3. doi: 10.1007/s00192-020-04369-3. Epub ahead of print. PMID: 32542466; PMCID: PMC7736065.
9: Parsons M, Robinson D, Cardozo L. Darifenacin in the treatment of overactive bladder. Int J Clin Pract. 2005 Jul;59(7):831-8. doi: 10.1111/j.1368-5031.2005.00585.x. PMID: 15963212.
10: Dubinskaya A. Commentary: effect of darifenacin on fecal incontinence in women with double incontinence. Int Urogynecol J. 2020 Jun 17. doi: 10.1007/s00192-020-04387-1. Epub ahead of print. PMID: 32556847.
