H-8208 trihydrochloride | CAS# 107882-63-3 | Biochemical

MedKoo Cat#: 576143 | Name: H-8208 trihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

H-8208 trihydrochloride is a benzimidazole dye that has been shown to intercalate into DNA.

Chemical Structure

H-8208 trihydrochloride

CAS#107882-63-3

Theoretical Analysis

MedKoo Cat#: 576143

Name: H-8208 trihydrochloride

CAS#: 107882-63-3

Chemical Formula: C18H24Cl3N5

Exact Mass: 415.1097

Molecular Weight: 416.77

Elemental Analysis: C, 51.87; H, 5.80; Cl, 25.52; N, 16.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

H-8208 trihydrochloride; H8208 trihydrochloride; H 8208 trihydrochloride; Hoechst 8208 trihydrochloride

IUPAC/Chemical Name

Benzenamine, 4-(5-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl)-, trihydrochloride

InChi Key

PGVHDHFKFINXBN-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H21N5.3ClH/c1-22-8-10-23(11-9-22)15-6-7-16-17(12-15)21-18(20-16)13-2-4-14(19)5-3-13;;;/h2-7,12H,8-11,19H2,1H3,(H,20,21);3*1H

SMILES Code

Cl.Cl.Cl.CN1CCN(CC1)c2ccc3[nH]c(nc3c2)c4ccc(N)cc4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 416.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Bardsley HJ, Sharples D, Grèzes JR. The binding of the benzimidazole dye H8208 to DNA and to polyinosinic-polycytidylic acid. J Pharm Pharmacol. 1987 Mar;39(3):212-4. doi: 10.1111/j.2042-7158.1987.tb06250.x. PMID: 2883286. 2. Hasegawa N, Kubota Y. Equilibrium and kinetic studies of the interaction of the benzimidazole dye Hoechst 8208 with nucleic acids. Nucleic Acids Symp Ser. 1993;(29):85-6. PMID: 8247805. 3. Nakamura H, Hifumi H, Kubota Y. The interaction of the benzimidazole dye Hoechst 8208 with nucleic acids. Nucleic Acids Symp Ser. 1990;(22):99-100. PMID: 2101927.