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MedKoo Cat#: 464148 | Name: BKI-1814

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BKI-1814 is a novel potent and selective bumped kinase inhibitor (BKI) CpCDPK1 IC50 0.005 µM.

Chemical Structure

BKI-1814
BKI-1814
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464148

Name: BKI-1814

CAS#: unknown

Chemical Formula: C22H23N5O2

Exact Mass: 389.1852

Molecular Weight: 389.46

Elemental Analysis: C, 67.85; H, 5.95; N, 17.98; O, 8.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BKI-1814; BKI1814; BKI 1814;
IUPAC/Chemical Name
5-(2-cyclopropoxyquinolin-6-yl)-7-(2-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
InChi Key
MHQWNGCNSZWRCO-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23N5O2/c1-22(2,28-3)27-11-16(19-20(23)24-12-25-21(19)27)13-4-8-17-14(10-13)5-9-18(26-17)29-15-6-7-15/h4-5,8-12,15H,6-7H2,1-3H3,(H2,23,24,25)
SMILES Code
NC1=C2C(N(C(C)(OC)C)C=C2C3=CC=C4N=C(OC5CC5)C=CC4=C3)=NC=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 389.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hulverson MA, Choi R, Vidadala RSR, Whitman GR, Vidadala VN, Ojo KK, Barrett LK, Lynch JJ, Marsh K, Kempf DJ, Maly DJ, Van Voorhis WC. Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis. ACS Infect Dis. 2021 Feb 10. doi: 10.1021/acsinfecdis.0c00803. Epub ahead of print. PMID: 33565854.