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MedKoo Cat#: 530496 | Name: DH-97

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DH-97 is a potent MT2 melatonin receptor antagonist (pKi value = 8.03).

Chemical Structure

DH-97
CAS#343263-95-6

Theoretical Analysis

MedKoo Cat#: 530496

Name: DH-97

CAS#: 343263-95-6

Chemical Formula: C22H26N2O

Exact Mass: 334.2045

Molecular Weight: 334.46

Elemental Analysis: C, 79.00; H, 7.84; N, 8.38; O, 4.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DH-97; DH 97; DH97.
IUPAC/Chemical Name
1-[3-(2-Aminoethyl)-2-(phenylmethyl)-1H-indol-1-yl]-1-pentanone
InChi Key
WQQBIBNCSCLVDX-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H26N2O/c1-2-3-13-22(25)24-20-12-8-7-11-18(20)19(14-15-23)21(24)16-17-9-5-4-6-10-17/h4-12H,2-3,13-16,23H2,1H3
SMILES Code
CCCCC(N1C(CC2=CC=CC=C2)=C(CCN)C3=C1C=CC=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Alarma-Estrany P, Guzman-Aranguez A, Huete F, Peral A, Plourde R Jr, Pelaez T, Yerxa B, Pintor J. Design of novel melatonin analogs for the reduction of intraocular pressure in normotensive rabbits. J Pharmacol Exp Ther. 2011 Jun;337(3):703-9. doi: 10.1124/jpet.110.178319. PubMed PMID: 21368006. 2: Fujinoki M. Melatonin-enhanced hyperactivation of hamster sperm. Reproduction. 2008 Nov;136(5):533-41. doi: 10.1530/REP-08-0202. PubMed PMID: 18715981. 3: Crooke A, Guzman-Aranguez A, Mediero A, Alarma-Estrany P, Carracedo G, Pelaez T, Peral A, Pintor J. Effect of melatonin and analogues on corneal wound healing: involvement of Mt2 melatonin receptor. Curr Eye Res. 2015 Jan;40(1):56-65. doi: 10.3109/02713683.2014.914540. PubMed PMID: 24892818. 4: Pintor J, Peláez T, Hoyle CH, Peral A. Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT3 receptor. Br J Pharmacol. 2003 Mar;138(5):831-6. PubMed PMID: 12642384; PubMed Central PMCID: PMC1573729. 5: Huete-Toral F, Crooke A, Martínez-Águila A, Pintor J. Melatonin receptors trigger cAMP production and inhibit chloride movements in nonpigmented ciliary epithelial cells. J Pharmacol Exp Ther. 2015 Jan;352(1):119-28. doi: 10.1124/jpet.114.218263. PubMed PMID: 25344385. 6: Behrens UD, Douglas RH, Sugden D, Davies DJ, Wagner HJ. Effect of melatonin agonists and antagonists on horizontal cell spinule formation and dopamine release in a fish retina. Cell Tissue Res. 2000 Mar;299(3):299-306. PubMed PMID: 10772244. 7: Kojima S, Tohei A, Ikeda M. Melatonin inhibits tachykinin NK₂ receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol. 2011 Mar;162(5):1179-85. doi: 10.1111/j.1476-5381.2010.01122.x. PubMed PMID: 21091649; PubMed Central PMCID: PMC3051389. 8: Chen Y, Tjong YW, Ip SF, Tipoe GL, Fung ML. Melatonin enhances the hypoxic response of rat carotid body chemoreceptor. J Pineal Res. 2005 Apr;38(3):157-63. PubMed PMID: 15725336. 9: Tu Y, Sun RQ, Willis WD. Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats. Pain. 2004 Jun;109(3):340-50. PubMed PMID: 15157695. 10: Tjong YW, Chen Y, Liong EC, Ip SF, Tipoe GL, Fung ML. Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis. J Pineal Res. 2004 Jan;36(1):49-57. PubMed PMID: 14675130. 11: Nosjean O, Nicolas JP, Klupsch F, Delagrange P, Canet E, Boutin JA. Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 . Biochem Pharmacol. 2001 Jun 1;61(11):1369-79. PubMed PMID: 11331072. 12: Hettihewa LM, Isuru A, Kalana J. Prospective encounter study of the degree of adherence to patient care indicators related to drug dispensing in Health Care facilities: A Sri Lankan perspective. J Pharm Bioallied Sci. 2011 Apr;3(2):298-301. doi: 10.4103/0975-7406.80769. PubMed PMID: 21687362; PubMed Central PMCID: PMC3103928. 13: Sjöblom M, Säfsten B, Flemström G. Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. Am J Physiol Gastrointest Liver Physiol. 2003 Jun;284(6):G1034-44. PubMed PMID: 12584110. 14: Requintina PJ, Oxenkrug GF. Effect of luzindole and other melatonin receptor antagonists on iron- and lipopolysaccharide-induced lipid peroxidation in vitro. Ann N Y Acad Sci. 2007 Dec;1122:289-94. PubMed PMID: 18077581. 15: Teh MT, Sugden D. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8. PubMed PMID: 9840420.

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