Cymiazole HCl | CAS# 121034-85-3 (HCl) | ectoparasiticide

MedKoo Cat#: 413426 | Name: Cymiazole HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cymiazole HCl is a veterinary drug used as an ectoparasiticide. It is also used to control Varroa mites in honeybees

Chemical Structure

Cymiazole HCl

CAS#121034-85-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 413426

Name: Cymiazole HCl

CAS#: 121034-85-3 (HCl)

Chemical Formula: C12H15ClN2S

Exact Mass: 254.0644

Molecular Weight: 254.78

Elemental Analysis: C, 56.57; H, 5.93; Cl, 13.91; N, 11.00; S, 12.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

121034-85-3 (HCl) 61676-87-7 (free base)

Synonym

Cymiazole HCl; Apitol; Cymiazole hydrochloride

IUPAC/Chemical Name

Benzenamine, 2,4-dimethyl-N-(3-methyl-2(3H)-thiazolylidene)-, hydrochloride (1:1)

InChi Key

WDSSGOOJORKJEC-USGGBSEESA-N

InChi Code

InChI=1S/C12H14N2S.ClH/c1-9-4-5-11(10(2)8-9)13-12-14(3)6-7-15-12;/h4-8H,1-3H3;1H/b13-12-;

SMILES Code

CN1/C(SC=C1)=N/C2=CC=C(C)C=C2C.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 254.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zheng W, Park JA, Abd El-Aty AM, Kim SK, Cho SH, Choi JM, Yi H, Cho SM, Ramadan A, Jeong JH, Shim JH, Shin HC. Development and validation of modified QuEChERS method coupled with LC-MS/MS for simultaneous determination of cymiazole, fipronil, coumaphos, fluvalinate, amitraz, and its metabolite in various types of honey and royal jelly. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:60-69. doi: 10.1016/j.jchromb.2017.11.011. Epub 2017 Nov 8. PubMed PMID: 29136552. 2: Boi M, Serra G, Colombo R, Lodesani M, Massi S, Costa C. A 10 year survey of acaricide residues in beeswax analysed in Italy. Pest Manag Sci. 2016 Jul;72(7):1366-72. doi: 10.1002/ps.4161. Epub 2015 Oct 27. PubMed PMID: 26423556. 3: Corta E, Bakkali A, Barranco A, Berrueta LA, Gallo B, Vicente F, Bogdanov S. Study of the degradation products of bromopropylate, chlordimeform, coumaphos, cymiazole, flumethrin and tau-fluvalinate in aqueous media. Talanta. 2000 Jun 21;52(2):169-80. PubMed PMID: 18967974. 4: Kryger U, Deschodt C, Davis AL, Scholtz CH. Effects of cattle treatment with a cypermethrin/cymiazol spray on survival and reproduction of the dung beetle species Euoniticellus intermedius (Coleoptera: Scarabaeidae). Bull Entomol Res. 2006 Dec;96(6):597-603. PubMed PMID: 17201977. 5: Stanimirovic Z, Stevanovic J, Jovanovic S, Andjelkovic M. Evaluation of genotoxic effects of Apitol (cymiazole hydrochloride) in vitro by measurement of sister chromatid exchange. Mutat Res. 2005 Dec 30;588(2):152-7. Epub 2005 Nov 23. PubMed PMID: 16309949. 6: Korta E, Bakkali A, Berrueta LA, Gallo B, Vicente F. Study of an accelerated solvent extraction procedure for the determination of acaricide residues in honey by high-performance liquid chromatography-diode array detector. J Food Prot. 2002 Jan;65(1):161-6. PubMed PMID: 11808788. 7: Korta E, Bakkali A, Berrueta LA, Gallo B, Vicente F, Kilchenmann V, Bogdanov S. Study of acaricide stability in honey. Characterization of amitraz degradation products in honey and beeswax. J Agric Food Chem. 2001 Dec;49(12):5835-42. PubMed PMID: 11743771. 8: Cabras P, Melis M, Spanedda L. Determination of cymiazole residues in honey by liquid chromatography. J AOAC Int. 1993 Jan-Feb;76(1):92-4. PubMed PMID: 8448449.