Cyclobenzaprine Free Base | CAS# 303-53-7 (free base) | muscle relaxant

MedKoo Cat#: 413409 | Name: Cyclobenzaprine Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyclobenzaprine Free Base is a muscle relaxant that can treat pain and stiffness caused by muscle spasms.

Chemical Structure

Cyclobenzaprine Free Base

CAS#303-53-7 (free base)

Theoretical Analysis

MedKoo Cat#: 413409

Name: Cyclobenzaprine Free Base

CAS#: 303-53-7 (free base)

Chemical Formula: C20H21N

Exact Mass: 275.1674

Molecular Weight: 275.39

Elemental Analysis: C, 87.23; H, 7.69; N, 5.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

303-53-7 (free base) 6202-23-9 (HCl)

Synonym

Cyclobenzaprine Free Base; Proheptatriene; Proheptatrien; Lisseril; Proeptatriene; Ciclobenzaprina; Fexmid; Cyclobenzaprinum; Ro 4-1577; Ro4-1577; Ro-4-1577; MK 130; MK130; MK-130

IUPAC/Chemical Name

1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-

InChi Key

JURKNVYFZMSNLP-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3

SMILES Code

CN(C)CC/C=C1C2=CC=CC=C2C=CC3=CC=CC=C\13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 275.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Khan I, Kahwaji CI. Cyclobenzaprine. 2020 Aug 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30020734. 2: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Cyclobenzaprine. 2017 Jan 30. PMID: 31644201. 3: Chaffee DM. Cyclobenzaprine in the Treatment of Low Back Pain. Am Fam Physician. 2016 Feb 1;93(3):Online. PMID: 26926618. 4: Long-term Use of Cyclobenzaprine for Pain: A Review of the Clinical Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Feb 23. PMID: 25763449. 5: Friedman BW, Dym AA, Davitt M, Holden L, Solorzano C, Esses D, Bijur PE, Gallagher EJ. Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA. 2015 Oct 20;314(15):1572-80. doi: 10.1001/jama.2015.13043. PMID: 26501533. 6: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Cyclobenzaprine. 2020 Jul 20. PMID: 30000455. 7: Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, Choy E, Kosek E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. 2017 Feb;76(2):318-328. doi: 10.1136/annrheumdis-2016-209724. Epub 2016 Jul 4. PMID: 27377815. 8: Cohen JY, Guilbault A. Induction of Psychosis by Cyclobenzaprine. Psychopharmacol Bull. 2018 Jun 20;48(4):15-19. PMID: 30618472; PMCID: PMC6294419. 9: Bulbena-Cabre A, Dunn NR, Swift RG. Cyclobenzaprine-Induced Hallucinosis. Prim Care Companion CNS Disord. 2015 Jun 25;17(3):10.4088/PCC.14l01773. doi: 10.4088/PCC.14l01773. PMID: 26644954; PMCID: PMC4578906. 10: Leite FM, Atallah AN, El Dib R, Grossmann E, Januzzi E, Andriolo RB, da Silva EM. Cyclobenzaprine for the treatment of myofascial pain in adults. Cochrane Database Syst Rev. 2009 Jul 8;2009(3):CD006830. doi: 10.1002/14651858.CD006830.pub3. PMID: 19588406; PMCID: PMC6481902.