Synonym
GW 471552; GW-471552; GW471552
IUPAC/Chemical Name
(1R,4S,4aR,7R,7aR,8aS)-8a-((((2R,6R)-4-cyclopropyl-6-methylmorpholin-2-yl)oxy)methyl)-4-formyl-3-isopropyl-7-methyl-4,4a,5,6,7,7a,8,8a-octahydro-1,4-methano-s-indacene-3a(1H)-carboxylic acid
InChi Key
AJSOAVVAYLEJRI-DIHXGBEDSA-N
InChi Code
InChI=1S/C28H41NO5/c1-16(2)23-9-19-10-26(14-30)22-8-5-17(3)21(22)11-27(19,28(23,26)25(31)32)15-33-24-13-29(20-6-7-20)12-18(4)34-24/h9,14,16-22,24H,5-8,10-13,15H2,1-4H3,(H,31,32)/t17-,18-,19+,21-,22-,24-,26+,27+,28?/m1/s1
SMILES Code
CC(C)C1=C[C@H]2C[C@]3(C=O)[C@@H]4CC[C@@H](C)[C@H]4C[C@@]2(CO[C@H]5CN(C[C@@H](C)O5)C6CC6)C13C(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
471.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Herreros E, Almela MJ, Lozano S, Gomez de las Heras F, Gargallo-Viola D. Antifungal activities and cytotoxicity studies of six new azasordarins. Antimicrob Agents Chemother. 2001 Nov;45(11):3132-9. doi: 10.1128/AAC.45.11.3132-3139.2001. PMID: 11600368; PMCID: PMC90794.
2. Jimenez E, Martínez A, Aliouat el M, Caballero J, Dei-Cas E, Gargallo-Viola D. Therapeutic efficacies of GW471552 and GW471558, two new azasordarin derivatives, against pneumocystosis in two immunosuppressed-rat models. Antimicrob Agents Chemother. 2002 Aug;46(8):2648-50. doi: 10.1128/aac.46.8.2648-2650.2002. PMID: 12121948; PMCID: PMC127331.
3. Martinez A, Ferrer S, Santos I, Jimenez E, Sparrowe J, Regadera J, De Las Heras FG, Gargallo-Viola D. Antifungal activities of two new azasordarins, GW471552 and GW471558, in experimental models of oral and vulvovaginal candidiasis in immunosuppressed rats. Antimicrob Agents Chemother. 2001 Dec;45(12):3304-9. doi: 10.1128/AAC.45.12.3304-3309.2001. PMID: 11709301; PMCID: PMC90830.
