MedKoo Cat#: 573998 | Name: Z-LRGG-AMC TFA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z-LRGG-AMC TFA is a fluorogenic substrate for isopeptidase T. Upon enzymatic cleavage by isopeptidase T, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify isopeptidase T activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

Chemical Structure

Z-LRGG-AMC TFA
Z-LRGG-AMC TFA
CAS#167698-68-2 (free base)

Theoretical Analysis

MedKoo Cat#: 573998

Name: Z-LRGG-AMC TFA

CAS#: 167698-68-2 (free base)

Chemical Formula: C36H45F3N8O10

Exact Mass: 0.0000

Molecular Weight: 806.80

Elemental Analysis: C, 53.59; H, 5.62; F, 7.06; N, 13.89; O, 19.83

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
25mg USD 850.00 2 Weeks
50mg USD 1,300.00 2 Weeks
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Related CAS #
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Synonym
Z-LRGG-AMC (trifluoroacetate salt), Z-Leu-Arg-Gly-Gly-AMC, Z-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin, Z-LRGG-AMC TFA
IUPAC/Chemical Name
benzyl ((S)-1-(((S)-5-((diaminomethylene)amino)-1-((2-((2-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)amino)-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate 2,2,2-trifluoroacetate
InChi Key
OHFBLWHOBJRDAB-CCQIZPNASA-N
InChi Code
InChI=1S/C34H44N8O8.C2HF3O2/c1-20(2)14-26(42-34(48)49-19-22-8-5-4-6-9-22)32(47)41-25(10-7-13-37-33(35)36)31(46)39-17-28(43)38-18-29(44)40-23-11-12-24-21(3)15-30(45)50-27(24)16-23;3-2(4,5)1(6)7/h4-6,8-9,11-12,15-16,20,25-26H,7,10,13-14,17-19H2,1-3H3,(H,38,43)(H,39,46)(H,40,44)(H,41,47)(H,42,48)(H4,35,36,37);(H,6,7)/t25-,26-;/m0./s1
SMILES Code
O=C1C=C(C)C2=C(C=C(NC(CNC(CNC([C@H](CCCNC(N)=N)NC([C@@H](NC(OCC3=CC=CC=C3)=O)CC(C)C)=O)=O)=O)=O)C=C2)O1.FC(F)(C(O)=O)F
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Emission: 440-460 nm Excitation: 340-360 nm λmax: 327 nm

Preparing Stock Solutions

The following data is based on the product molecular weight 806.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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