Flutamide-d7 | CAS#223134-72-3 | Flutamide quantification internal standard

MedKoo Cat#: 464110 | Name: Flutamide-d7

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft model. Formulations containing flutamide have been used in the treatment of prostate cancer.

Chemical Structure

Flutamide-d7

CAS#223134-72-3 (d7)

Theoretical Analysis

MedKoo Cat#: 464110

Name: Flutamide-d7

CAS#: 223134-72-3 (d7)

Chemical Formula: C11H4D7F3N2O3

Exact Mass: 283.1161

Molecular Weight: 283.26

Elemental Analysis: C, 46.64; H, 6.40; F, 20.12; N, 9.89; O, 16.94

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 450.00	2 Weeks

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Related CAS #

223134-72-3 (d7) 13311-84-7

Synonym

Flutamide-d7; Flutamide d7; Niftolide-d7; Niftolide d7;

IUPAC/Chemical Name

2-(methyl-d3)-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide

InChi Key

MKXKFYHWDHIYRV-NWOXSKRJSA-N

InChi Code

InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)/i1D3,2D3,6D

SMILES Code

FC(C1=C([N+]([O-])=O)C=CC(NC(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C1)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 283.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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ABT-239

MedKoo CAT#: 524114

CAS#: 460746-46-7