Norzimelidine | CAS# 56775-85-0 | N-demethylated metabolite of zimelidine

MedKoo Cat#: 413336 | Name: Norzimelidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norzimelidine is a pharmacologically active N-demethylated metabolite of zimelidine.

Chemical Structure

Norzimelidine

CAS#56775-85-0

Theoretical Analysis

MedKoo Cat#: 413336

Name: Norzimelidine

CAS#: 56775-85-0

Chemical Formula: C15H15BrN2

Exact Mass: 302.0419

Molecular Weight: 303.20

Elemental Analysis: C, 59.42; H, 4.99; Br, 26.35; N, 9.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Norzimelidine; CPP199; CPP-199; CPP 199

IUPAC/Chemical Name

2-Propen-1-amine, 3-(4-bromophenyl)-N-methyl-3-(3-pyridinyl)-

InChi Key

AZFZKANGXPSDEA-NVNXTCNLSA-N

InChi Code

InChI=1S/C15H15BrN2/c1-17-10-8-15(13-3-2-9-18-11-13)12-4-6-14(16)7-5-12/h2-9,11,17H,10H2,1H3/b15-8-

SMILES Code

CNC/C=C(C1=CC=C(Br)C=C1)\C2=CC=CN=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 303.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Caillé G, Kouassi E, de Montigny C. Pharmacokinetic study of zimelidine using a new GLC method. Clin Pharmacokinet. 1983 Nov-Dec;8(6):530-40. doi: 10.2165/00003088-198308060-00004. PMID: 6228368. 2: Harms HH. The antidepressant agents desipramine, fluoxetine, fluvoxamine and norzimelidine inhibit uptake of [3H]noradrenaline and [3H]5-hydroxytryptamine in slices of human and rat cortical brain tissue. Brain Res. 1983 Sep 19;275(1):99-104. doi: 10.1016/0006-8993(83)90421-3. PMID: 6226337. 3: Pawłowski L, Mazela H. Norzimelidine, a metabolite of a highly selective 5-hydroxytryptamine uptake inhibitor, can inhibit the uptake of noradrenaline in-vivo. J Pharm Pharmacol. 1984 Dec;36(12):855-8. doi: 10.1111/j.2042-7158.1984.tb04896.x. PMID: 6151986. 4: Love BL, Moore RG, Thomas J, Chaturvedi S. Pharmacokinetics of zimelidine in humans--plasma levels and urinary excretion of zimelidine and norzimelidine after intravenous and oral administration of zimelidine. Eur J Clin Pharmacol. 1981;20(2):135-9. doi: 10.1007/BF00607150. PMID: 6455297. 5: Emanuelsson B. Quantitation of zimelidine and norzimelidine in plasma using high-performance liquid chromatography. J Chromatogr. 1978 Jul 1;146(1):113-7. doi: 10.1016/s0378-4347(00)81295-5. PMID: 670347. 6: Brown D, Scott DH, Scott DB, Meyer M, Westerlund D, Lundström J. Pharmacokinetics of zimelidine. Systemic availability of zimelidine and norzimelidine in human volunteers. Eur J Clin Pharmacol. 1980 Feb;17(2):111-6. doi: 10.1007/BF00562618. PMID: 6445274. 7: Montgomery SA, Montgomery DB, McAuley R, Rani SJ, Roy D. Profile of antidepressant action of zimelidine and norzimelidine compared with amitriptyline. Adv Biochem Psychopharmacol. 1982;32:35-42. PMID: 6211942. 8: Calil HM, Jostell KG, Cowdry RW, Potter WZ. Zimelidine and norzimelidine protein binding measured by equilibrium dialysis and cerebrospinal fluid. Clin Pharmacol Ther. 1982 Apr;31(4):522-7. doi: 10.1038/clpt.1982.70. PMID: 6460587. 9: Hansen LB, Thomsen IS, Vestergård P, Larsen NE, Hvidberg EF. Plasma levels of zimelidine and norzimelidine in endogenous depression. Psychopharmacology (Berl). 1980;69(2):157-60. doi: 10.1007/BF00427642. PMID: 6450427. 10: Humphreys CJ, Levin J, Rudnick G. Antidepressant binding to the porcine and human platelet serotonin transporters. Mol Pharmacol. 1988 Jun;33(6):657-63. PMID: 3380080.