Synonym
Alloxantin; Uroxin; Uroxine; NSC 7634; NSC7634; NSC-7634;
IUPAC/Chemical Name
5,5'-dihydroxy-[5,5'-bipyrimidine]-2,2',4,4',6,6'(1H,1'H,3H,3'H,5H,5'H)-hexaone
InChi Key
IWDDXZKCDHOOSF-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H6N4O8/c13-1-7(19,2(14)10-5(17)9-1)8(20)3(15)11-6(18)12-4(8)16/h19-20H,(H2,9,10,13,14,17)(H2,11,12,15,16,18)
SMILES Code
OC1(C2(C(NC(NC2=O)=O)=O)O)C(NC(NC1=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
286.16
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ponce AM, Blanco SE, Molina AS, García-Domenech R, Gálvez J. Study of the action of flavonoids on xanthine-oxidase by molecular topology. J Chem Inf Comput Sci. 2000 Jul-Aug;40(4):1039-45. doi: 10.1021/ci000020k. PMID: 10955535.
2: Tamura M, Konishi F, Inagami T. A novel endogenous sodium-pump inhibitor in pig urine: purification and comparison with the inhibitor purified from bovine adrenal glands. J Cardiovasc Pharmacol. 1993;22 Suppl 2:S47-50. PMID: 7508027.
3: Lenzen S, Munday R. Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin. Biochem Pharmacol. 1991 Sep 12;42(7):1385-91. doi: 10.1016/0006-2952(91)90449-f. PMID: 1930261.
4: Clay RJ, Knevel AM, Byrn SR. The desolvation and oxidation of crystals of dialuric acid monohydrate. J Pharm Sci. 1982 Nov;71(11):1289-91. doi: 10.1002/jps.2600711127. PMID: 7175727.
5: Horton GL, Huyser ES, Akagi JM. The behavior of alloxan in the Hill reaction. Experientia. 1976;32(7):861-2. doi: 10.1007/BF02003731. PMID: 954965.
6: Anghileri LJ. Calcium metabolism in tumors, its relationship with chromium complex accumulation. IV. 51 Cr-alloxantin incorporation and calcium-phosphorus composition. Oncology. 1971;25(5):425-38. doi: 10.1159/000224593. PMID: 4335472.
7: Benson B, Snipes W. Free radicals in pyrimidines: E.S.R. of gamma-irradiated single crystals of alloxantin. Int J Radiat Biol Relat Stud Phys Chem Med. 1969;15(6):583-5. doi: 10.1080/09553006914550891. PMID: 4309918.
8: Singh C. The structure of the pyrimidines and purines. IX. The crystal structure of alloxantin dihydrate. Acta Crystallogr. 1965 Nov 10;19(5):767-74. doi: 10.1107/s0365110x65004346. PMID: 5897689.
9: ABDERHALDEN E. Beitrag zum Problem der Alloxantin-, Ninhydrin- und Ninhydrinharnstoffwirkung auf den tierischen Organismus; Beobachtung des Auftretens von Homogentisinsäure, p-Oxyphenyl-brenztrauben- und Xanthurensäure bei Ratten bzw. Mäusen [Contribution to the problem of the alloxantine, ninhydrin and ninhydrin urea effects on the animal organism; Observation of the occurrence of homogentisic acid, p-oxyphenyl pyruvic acid and xanthurenic acid in rats and mice]. Z Vitam Horm Fermentforsch. 1947;1(3-4):241-56. German. PMID: 18906508.
10: HERBUT PA, WATSON JS, PERKINS E. Alloxantin; an investigation of the substance as used in experimental production of diabetes. Arch Pathol (Chic). 1946 Aug;42:214-21. PMID: 20999921.
11: Hill ES, Michaelis L. THE EFFECT OF IRON ON THE ESTABLISHMENT OF THE OXIDATION-REDUCTION POTENTIAL OF ALLOXANTIN. Science. 1933 Nov 24;78(2030):485-6. doi: 10.1126/science.78.2030.485. PMID: 17818951.
