Synonym
Chinoin 170; Chinoin-170; Chinoin170
IUPAC/Chemical Name
1,3-dimethyl-7-((5-methyl-1,2,4-oxadiazol-3-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
InChi Key
JBXSBZBZASARMY-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12N6O3/c1-6-13-7(14-20-6)4-17-5-12-9-8(17)10(18)16(3)11(19)15(9)2/h5H,4H2,1-3H3
SMILES Code
O=C(N1C)N(C)C2=C(N(CC3=NOC(C)=N3)C=N2)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
276.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Saano V, Minker E, Joki S, Virta P, Nuutinen J, Korbonits D. Influence of chinoin-170, a novel antitussive, on the mucociliary activity in respiratory airways of rats, rabbits, guinea-pigs and man. J Pharm Pharmacol. 1993 Sep;45(9):799-802. doi: 10.1111/j.2042-7158.1993.tb05688.x. PMID: 7903367.
2: Bolehovszky A, Szatmári I, Várkonyi P, Fritsch S, Vargay Z. Chinoin-170 farmakokinetikája patkányban és kutyában [Pharmacokinetics of Chinoin-170 in rats and dogs]. Acta Pharm Hung. 1989;59 Suppl 1:32-7. Hungarian. PMID: 2701628.
3: Okumura M, Tsuruoka M, Isohama Y, Kai H, Takahama K, Miyata T. Effects of xanthine derivatives on phosphatidylcholine secretion in primary culture of rat type II pneumocytes. Jpn J Pharmacol. 1995 Feb;67(2):165-8. doi: 10.1254/jjp.67.165. PMID: 7616691.
