Formocortal | CAS# 2825-60-7 | corticosteroid

MedKoo Cat#: 413294 | Name: Formocortal

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Formocortal is a corticosteroid used in ophthalmology

Chemical Structure

Formocortal

CAS#2825-60-7

Theoretical Analysis

MedKoo Cat#: 413294

Name: Formocortal

CAS#: 2825-60-7

Chemical Formula: C29H38ClFO8

Exact Mass: 568.2239

Molecular Weight: 569.06

Elemental Analysis: C, 61.21; H, 6.73; Cl, 6.23; F, 3.34; O, 22.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Formocortal; fluoroformylone; Fluderma; Deflamene; FI6341; FI-6341; FI 6341; NSC 150527; NSC-150527; NSC150527;

IUPAC/Chemical Name

Pregna-3,5-diene-6-carboxaldehyde, 21-(acetyloxy)-3-(2-chloroethoxy)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-20-oxo-, (11beta,16alpha)-

InChi Key

QNXUUBBKHBYRFW-UDWCLICTSA-N

InChi Code

InChI=1S/C29H38ClFO8/c1-16(33)37-15-23(35)29-24(38-25(2,3)39-29)12-20-21-10-17(14-32)19-11-18(36-9-8-30)6-7-26(19,4)28(21,31)22(34)13-27(20,29)5/h11,14,20-22,24,34H,6-10,12-13,15H2,1-5H3/t20-,21-,22-,24-,26-,27-,28-,29+/m0/s1

SMILES Code

C[C@@]12[C@@]3(C(COC(C)=O)=O)[C@](OC(C)(O3)C)([H])C[C@@]1([H])[C@]4([H])CC(C=O)=C5C=C(OCCCl)CC[C@]5(C)[C@@]4(F)[C@@H](O)C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 569.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bertazzoli C, Chieli T, Ricevuti G. Formocortal: studio sperimentale della tollerabilitá acuta e cronica [Formocortal: experimental study of its acute and chronic toxicity]. Eur J Toxicol. 1971 Sep-Oct;4(5):432-40. Italian. PMID: 5150101. 2: Marchese A, Bozzolasco M, Gualco L, Schito GC, Debbia EA. Evaluation of spontaneous contamination of ocular medications. Chemotherapy. 2001 Jul- Aug;47(4):304-8. doi: 10.1159/000048538. PMID: 11399868. 3: Aliperta G, Lattaro R. Sull'impiego topico di un nuovo steroide, il formoocortal, nel trattamento delle flebodermiti e negli innesti auto ed omoplastici i cute [On the topical use of a new steroid, formocortal, in the treatment of phlebodermitis and in cutaneous auto- and homo-grafts]. Minerva Cardioangiol. 1971 Nov;19(11):620-4. Italian. PMID: 4942789. 4: Sala G, Castegnaro E. Caratteristiche farmacocinetiche e metaboliche di un nuovo dermosteroide: il Formocortal [Pharmacodynamic and metabolic characteristics of a new dermosteroid: Formocortal]. G Ital Dermatol Minerva Dermatol. 1970 Jul;45(7):451-62. Italian. PMID: 5537424. 5: Buzzoni A, Guarneri B. Esperienze cliniche con un nuovo steroide cortisonico per uso topico: il formocortal [Clinical experience with a new corticosteroid for topical use: formocortal]. G Ital Dermatol Minerva Dermatol. 1969 Dec;44(12):673-6. Italian. PMID: 4243641.