DS12881479 | A MNK1 inhibitor | CAS#2373065-59-7

MedKoo Cat#: 128885 | Name: DS12881479

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DS12881479 is a MNK1 inhibitor.

Chemical Structure

DS12881479

CAS#2373065-59-7

Theoretical Analysis

MedKoo Cat#: 128885

Name: DS12881479

CAS#: 2373065-59-7

Chemical Formula: C16H19N3OS

Exact Mass: 301.1249

Molecular Weight: 301.41

Elemental Analysis: C, 63.76; H, 6.35; N, 13.94; O, 5.31; S, 10.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DS12881479; DS-12881479; DS 12881479

IUPAC/Chemical Name

1-methyl-N-(5-phenylthiazol-2-yl)piperidine-4-carboxamide

InChi Key

BTZKRRFKIKIADV-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H19N3OS/c1-19-9-7-13(8-10-19)15(20)18-16-17-11-14(21-16)12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3,(H,17,18,20)

SMILES Code

O=C(C1CCN(C)CC1)NC2=NC=C(S2)C3=CC=CC=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 301.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yang Z, Liu Y, Liao Z, Chen L, Liang Z, Zhang L, Li Z. Discovery of P11-2: A Potent First-in-Class MNK1-Targeting PROTAC Degrader for the Treatment of Cancer. J Med Chem. 2025 May 7. doi: 10.1021/acs.jmedchem.5c00062. Epub ahead of print. PMID: 40334145. 2: Matsui Y, Yasumatsu I, Yoshida KI, Iimura S, Ikeno Y, Nawano T, Fukano H, Ubukata O, Hanzawa H, Tanzawa F, Isoyama T. A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1. Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):156-160. doi: 10.1107/S2053230X18002108. Epub 2018 Feb 26. PMID: 29497019; PMCID: PMC5947701.