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MedKoo Cat#: 464029 | Name: M826

Description:

WARNING: This product is for research use only, not for human or veterinary use.

M826 is a neuroprotective agent.

Chemical Structure

M826
M826
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464029

Name: M826

CAS#: unknown

Chemical Formula: C28H45N7O6

Exact Mass: 575.3431

Molecular Weight: 575.71

Elemental Analysis: C, 58.42; H, 7.88; N, 17.03; O, 16.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
M826; M 826; M-826;
IUPAC/Chemical Name
3-((S)-2-(5-(tert-butyl)-3-(((4-methyl-1,2,5-oxadiazol-3-yl)methyl)amino)-2-oxopyrazin-1(2H)-yl)butanamido)-5-(hexyl(methyl)amino)-4-oxopentanoic acid
InChi Key
XIMITGPWYYFUQF-QWAKEFERSA-N
InChi Code
InChI=1S/C28H45N7O6/c1-8-10-11-12-13-34(7)16-22(36)19(14-24(37)38)30-26(39)21(9-2)35-17-23(28(4,5)6)31-25(27(35)40)29-15-20-18(3)32-41-33-20/h17,19,21H,8-16H2,1-7H3,(H,29,31)(H,30,39)(H,37,38)/t19?,21-/m0/s1
SMILES Code
CC1=NON=C1CNC2=NC(C(C)(C)C)=CN([C@@H](CC)C(NC(CC(O)=O)C(CN(CCCCCC)C)=O)=O)C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 575.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Seven days in medicine: 26 Feb to 3 Mar 2020. BMJ. 2020 Mar 4;368:m826. doi: 10.1136/bmj.m826. PMID: 32139441. 2: Yu F, Song H, Wu Y, Chang SY, Wang L, Li W, Hong B, Xia S, Wang C, Khurana S, Feng Y, Wang Y, Sun Z, He B, Hou D, Manischewitz J, King LR, Song Y, Min JY, Golding H, Ji X, Lu L, Jiang S, Dimitrov DS, Ying T. A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin. Cell Host Microbe. 2017 Oct 11;22(4):471-483.e5. doi: 10.1016/j.chom.2017.08.011. Epub 2017 Sep 28. PMID: 28966056; PMCID: PMC6290738. 3: Chen H, Xu H. Poly[(μ(2)-benzene-1,3-dicarboxyl- ato-κ(2)O(1):O(3)){μ(2)-1,2-bis-[(1H-imidazol-1-yl)meth- yl]benzene-κ(2)N(3):N(3')}zinc]. Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):m826. doi: 10.1107/S1600536812022544. Epub 2012 May 26. PMID: 22719367; PMCID: PMC3379146. 4: Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J, Tawa P, Nicholson DW, Zamboni RJ. Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. doi: 10.1016/j.bmcl.2004.12.006. PMID: 15686936. 5: Toulmond S, Tang K, Bureau Y, Ashdown H, Degen S, O'Donnell R, Tam J, Han Y, Colucci J, Giroux A, Zhu Y, Boucher M, Pikounis B, Xanthoudakis S, Roy S, Rigby M, Zamboni R, Robertson GS, Ng GY, Nicholson DW, Flückiger JP. Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease. Br J Pharmacol. 2004 Feb;141(4):689-97. doi: 10.1038/sj.bjp.0705662. Epub 2004 Jan 26. PMID: 14744804; PMCID: PMC1574244. 6: Han BH, Xu D, Choi J, Han Y, Xanthoudakis S, Roy S, Tam J, Vaillancourt J, Colucci J, Siman R, Giroux A, Robertson GS, Zamboni R, Nicholson DW, Holtzman DM. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury. J Biol Chem. 2002 Aug 16;277(33):30128-36. doi: 10.1074/jbc.M202931200. Epub 2002 Jun 10. PMID: 12058036.