Oxacyclododecindione | CAS#N/A | IL-4 signaling pathway inhibitor

MedKoo Cat#: 130256 | Name: Oxacyclododecindione

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxacyclododecindione is an inhibitor of the expression of SEAP induced by IL-4. Oxacyclododecindione prevents the binding of activated STAT6 transcription factors with DNA, which in turn, blocks the IL-4 signaling pathway. Oxacyclododecindione shows promise in treating inflammatory diseases.

Chemical Structure

Oxacyclododecindione

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130256

Name: Oxacyclododecindione

CAS#: N/A

Chemical Formula: C18H21ClO6

Exact Mass: 368.1027

Molecular Weight: 368.81

Elemental Analysis: C, 58.62; H, 5.74; Cl, 9.61; O, 26.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Oxacyclododecindione

IUPAC/Chemical Name

(E)-14-chloro-5,11,13-trihydroxy-4,5,9-trimethyl-4,5,6,7-tetrahydro-2H-benzo[d][1]oxacyclododecine-2,10(1H)-dione

InChi Key

CKSXTSLBLCBNFG-WEVVVXLNSA-N

InChi Code

InChI=1S/C18H21ClO6/c1-9-5-4-6-18(3,24)10(2)25-14(22)7-11-15(17(9)23)12(20)8-13(21)16(11)19/h5,8,10,20-21,24H,4,6-7H2,1-3H3/b9-5+

SMILES Code

O=C(CC1=C(Cl)C(O)=CC(O)=C12)OC(C)C(C)(O)CC/C=C(C)/C2=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 368.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Erkel G, Belahmer H, Serwe A, Anke T, Kunz H, Kolshorn H, Liermann J, Opatz T. Oxacyclododecindione, a novel inhibitor of IL-4 signaling from Exserohilum rostratum. J Antibiot (Tokyo). 2008 May;61(5):285-90. doi: 10.1038/ja.2008.40. PMID: 18653993. 2. Tauber J, Rohr M, Walter T, Erkel G, Opatz T. Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type. Org Biomol Chem. 2015 Jul 28;13(28):7813-21. doi: 10.1039/c5ob01044f. Epub 2015 Jun 24. Erratum in: Org Biomol Chem. 2015 Sep 7;13(33):8945-6. PMID: 26106910. 3. Henke J, Erkel G, Brochhausen C, Kleinert H, Schwarting A, Menke J, Pautz A. The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease. Kidney Int. 2014 Oct;86(4):780-9. doi: 10.1038/ki.2014.109. Epub 2014 Apr 9. PMID: 24717299.