Synonym
Conorphone HCl; TR5109; TR-5109; TR 5109; Conorphone Hydrochloride;
IUPAC/Chemical Name
17-(Cyclopropylmethyl)-4,5alpha-epoxy-8beta-ethyl-3-methoxymorphinan-6-one hydrochloride
InChi Key
CKEXIRBGGMFWOA-YDSJSODMSA-N
InChi Code
InChI=1S/C23H29NO3.ClH/c1-3-14-11-17(25)22-23-8-9-24(12-13-4-5-13)16(19(14)23)10-15-6-7-18(26-2)21(27-22)20(15)23;/h6-7,13-14,16,19,22H,3-5,8-12H2,1-2H3;1H/t14-,16-,19+,22-,23+;/m1./s1
SMILES Code
[H][C@]1([C@]2([C@@H]3O4)C5=C4C(OC)=CC=C5C[C@H]1N(CC6CC6)CC2)[C@H](CC)CC3=O.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
403.95
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dionne RA, Wirdezk PR, Butler DP, Fox PC. Comparison of conorphone, a mixed agonist-antagonist analgesic, to codeine for postoperative dental pain. Anesth Prog. 1984 Mar-Apr;31(2):77-81. PMID: 6597688; PMCID: PMC2515536.
2: Nekrassov V, Peón JM. Efecto de la conorfona sobre las dimensiones del infarto del miocardio y las alteraciones ultraestrcuturales del tejido adyacente [Effect of conorphone on the dimensions of the myocardial infarct and the ultrastructural changes in the adjacent tissue]. Arch Inst Cardiol Mex. 1988 Nov-Dec;58(6):505-9. Spanish. PMID: 3245720.
3: Peón J, Ruiz-González M. Electrophysiological effects of morphine, naloxone and conorphone on cardiac Purkinje fibers. Proc West Pharmacol Soc. 1991;34:255-9. PMID: 1788294.
4: Leeling JL, Evans JV, Helms RJ, Ryerson BA. Disposition and metabolism of codorphone in the rat, dog, and man. Drug Metab Dispos. 1982 Nov- Dec;10(6):649-53. PMID: 6130916.
5: Howes JF. A simple, reliable method for predicting the physical dependence liability of narcotic antagonist analgesics in the rat. Pharmacol Biochem Behav. 1981 May;14(5):689-92. doi: 10.1016/0091-3057(81)90132-5. PMID: 6113607.
6: Howes JF, Osgood PF, Razdan RK, Moreno F, Castro A, Villareal J. The pharmacology of TR5109, a new narcotic agonist/antagonist analgesic. NIDA Res Monogr. 1979;27:99-105. PMID: 121369.
7: Evans JV, Leeling JL, Helms RJ. Methodology for the identification of the urinary metabolites of the analgesic-narcotic antagonist, codorphone, by gas chromatography mass spectrometry. Biomed Mass Spectrom. 1982 May;9(5):191-200. doi: 10.1002/bms.1200090504. PMID: 6124285.
