MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 413230 | Name: Colesevelam (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Colesevelam (free base) is a cross-linked terpolymer of N-decyl-N-allylamine, N-(6-trimethylammoniumhexyl)-N-allylamine and allylamine; a bile acid sequestrant. It is a Cholesterol medication that can lower cholesterol levels and treat type 2 diabetes.

Chemical Structure

Colesevelam (free base)
Colesevelam (free base)
CAS#182815-43-6 (free base)

Theoretical Analysis

MedKoo Cat#: 413230

Name: Colesevelam (free base)

CAS#: 182815-43-6 (free base)

Chemical Formula: C31H66Cl2N4O

Exact Mass: 580.4614

Molecular Weight: 581.79

Elemental Analysis: C, 64.00; H, 11.43; Cl, 12.19; N, 9.63; O, 2.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
182815-43-6 (free base) 182815-44-7 (HCl)
Synonym
Colesevelam (free base); HSDB7925; HSDB-7925; HSDB 7925
IUPAC/Chemical Name
1-Hexaminium, N,N,N-trimethyl-6-(2-propenylamino)-, chloride, polymer with (chloromethyl)oxirane, 2-propen-4-amine and N-2-propenyl-1-decanamine
InChi Key
NXOLVMFMAFCDSR-UHFFFAOYSA-M
InChi Code
InChI=1S/C13H27N.C12H27N2.C3H5ClO.C3H7N.ClH/c1-3-5-6-7-8-9-10-11-13-14-12-4-2;1-5-10-13-11-8-6-7-9-12-14(2,3)4;4-1-3-2-5-3;1-2-3-4;/h4,14H,2-3,5-13H2,1H3;5,13H,1,6-12H2,2-4H3;3H,1-2H2;2H,1,3-4H2;1H/q;+1;;;/p-1
SMILES Code
CCCCCCCCCCNCC=C.C[N+](C)(CCCCCCNCC=C)C.NCC=C.ClCC1CO1.[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 581.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Patel PH, Can AS. Colesevelam. 2020 Nov 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 32491747. 2: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Colesevelam. 2017 Sep 28. PMID: 31644180. 3: Melian EB, Plosker GL. Colesevelam. Am J Cardiovasc Drugs. 2001;1(2):141-6; discussion 147-8. doi: 10.2165/00129784-200101020-00007. PMID: 14728043. 4: Nerild HH, Christensen MB, Knop FK, Brønden A. Preclinical discovery and development of colesevelam for the treatment of type 2 diabetes. Expert Opin Drug Discov. 2018 Dec;13(12):1161-1167. doi: 10.1080/17460441.2018.1538206. Epub 2018 Oct 23. PMID: 30336707. 5: Steinmetz KL. Colesevelam hydrochloride. Am J Health Syst Pharm. 2002 May 15;59(10):932-9. doi: 10.1093/ajhp/59.10.932. PMID: 12040732. 6: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Colesevelam. 2018 Oct 31. PMID: 30000454. 7: Kalra S, Priya G, Aggarwal S. Colesevelam in the management of type 2 diabetes. J Pak Med Assoc. 2020 May;70(5):934-936. PMID: 32400758. 8: Robinson DM, Keating GM. Colesevelam: a review of its use in hypercholesterolemia. Am J Cardiovasc Drugs. 2007;7(6):453-65. doi: 10.2165/00129784-200707060-00009. PMID: 18076213. 9: Ooi CP, Loke SC. Colesevelam for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD009361. doi: 10.1002/14651858.CD009361.pub2. PMID: 23235674; PMCID: PMC6486226. 10: Perry CM. Colesevelam: in pediatric patients with heterozygous familial hypercholesterolemia. Paediatr Drugs. 2010 Apr 1;12(2):133-40. doi: 10.2165/11204890-000000000-00000. PMID: 20218749.