Synonym
5LUB; 5 LUB; 5-LUB; δ-Secretase Inhibitor 11; delta-Secretase Inhibitor 11
IUPAC/Chemical Name
7-morpholinobenzo[c][1,2,5]oxadiazol-4-amine
InChi Key
LWCSTSZSZFUHAT-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H12N4O2/c11-7-1-2-8(10-9(7)12-16-13-10)14-3-5-15-6-4-14/h1-2H,3-6,11H2
SMILES Code
NC1=CC=C(N2CCOCC2)C3=NON=C31
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
220.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Isaacson RH, Carrasco DI, Holliday H, Kang SS, Khan S, Kim D, Liu X, Ye K,
English AW. Treatments with the specific δ-secretase inhibitor, compound 11,
promote the regeneration of motor and sensory axons after peripheral nerve
injury. Eur J Neurosci. 2023 Sep;58(6):3555-3568. doi: 10.1111/ejn.16126. Epub
2023 Aug 22. PMID: 37608574.
2: Wang J, Hu HJ, Liu ZK, Liu JJ, Wang SS, Cheng Q, Chen HZ, Song M.
Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor
11 mitigates Alzheimer's disease-related pathologies in a senescence-accelerated
mouse model. Transl Neurodegener. 2021 Mar 31;10(1):12. doi:
10.1186/s40035-021-00235-4. PMID: 33789744; PMCID: PMC8015189.
3: Qian Z, Li B, Meng X, Liao J, Wang G, Li Y, Luo Q, Ye K. Inhibition of
asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease
in mice. Neuropsychopharmacology. 2024 Feb;49(3):620-630. doi:
10.1038/s41386-023-01774-2. Epub 2023 Nov 29. PMID: 38030711; PMCID:
PMC10789813.
4: Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP,
Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K. Inhibition of delta-
secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun. 2017 Mar 27;8:14740. doi: 10.1038/ncomms14740. PMID: 28345579;
PMCID: PMC5378956.
