MDL 100748 | CAS# 130613-18-2 | antagonist of NMDA receptor

MedKoo Cat#: 413209 | Name: MDL 100748

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDL 100748 is a glycine site antagonist of NMDA receptor.

Chemical Structure

MDL 100748

CAS#130613-18-2

Theoretical Analysis

MedKoo Cat#: 413209

Name: MDL 100748

CAS#: 130613-18-2

Chemical Formula: C12H8Cl2N2O4

Exact Mass: 313.9861

Molecular Weight: 315.11

Elemental Analysis: C, 45.74; H, 2.56; Cl, 22.50; N, 8.89; O, 20.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MDL 100748; Mdl-100748; Mdl100748

IUPAC/Chemical Name

2-Quinolinecarboxylic acid, 4-((carboxymethyl)amino)-5,7-dichloro-

InChi Key

UJAOIPMPKPYADL-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H8Cl2N2O4/c13-5-1-6(14)11-7(15-4-10(17)18)3-9(12(19)20)16-8(11)2-5/h1-3H,4H2,(H,15,16)(H,17,18)(H,19,20)

SMILES Code

O=C(C1=NC2=CC(Cl)=CC(Cl)=C2C(NCC(O)=O)=C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 315.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Baron BM, Harrison BL, McDonald IA, Meldrum BS, Palfreyman MG, Salituro FG, Siegel BW, Slone AL, Turner JP, White HS. Potent indole- and quinoline- containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. PMID: 1388205. 2: Harrison BL, Baron BM, Cousino DM, McDonald IA. 4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl- D-aspartate receptor complex. J Med Chem. 1990 Dec;33(12):3130-2. doi: 10.1021/jm00174a005. PMID: 2147957.