Lodaxaprine | CAS# 93181-81-8 | anticonvulsant

MedKoo Cat#: 413207 | Name: Lodaxaprine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lodaxaprine is an anticonvulsant agent

Chemical Structure

Lodaxaprine

CAS#93181-81-8

Theoretical Analysis

MedKoo Cat#: 413207

Name: Lodaxaprine

CAS#: 93181-81-8

Chemical Formula: C15H16ClN3O

Exact Mass: 289.0982

Molecular Weight: 289.76

Elemental Analysis: C, 62.18; H, 5.57; Cl, 12.23; N, 14.50; O, 5.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Lodaxaprine; CM40907; CM-40907; CM 40907

IUPAC/Chemical Name

1-(6-(o-Chlorophenyl)-3-pyridazinyl)-4-piperidinol

InChi Key

USEZRIFSJXAMJD-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H16ClN3O/c16-13-4-2-1-3-12(13)14-5-6-15(18-17-14)19-9-7-11(20)8-10-19/h1-6,11,20H,7-10H2

SMILES Code

OC1CCN(C2=NN=C(C3=CC=CC=C3Cl)C=C2)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 289.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chambon JP, Brochard J, Hallot A, Heaulme M, Brodin R, Roncucci R, Biziere K. CM 40907: a structurally novel anticonvulsant in mice, rats and baboons. J Pharmacol Exp Ther. 1985 Jun;233(3):836-44. PMID: 2989499. 2: Stanková L, Mares P. Antimetrazol action of two potential anticonvulsants, CM 40907 and SR 41378, in immature rats. Physiol Res. 1992;41(6):451-7. PMID: 1299328. 3: Schaffler K, Wauschkuhn CH, Gierend M. Analgesic potency of a new anticonvulsant drug versus acetylsalicylic acid via laser somatosensory evoked potentials. Randomized placebo-controlled double-blind (5-way) crossover study. Arzneimittelforschung. 1991 Apr;41(4):427-35. PMID: 1859518. 4: Perio A, Chambon JP, Calassi R, Heaulme M, Biziere K. Evaluation of two anticonvulsant amino-pyridazine derivatives in the conflict test in rats. J Pharmacol Exp Ther. 1986 Nov;239(2):542-7. PMID: 3095540. 5: Yepez-Lasso R, Duncan JS, Shorvon SD. Suppression of inter-ictal spikes by CM40907. A double-blind placebo-controlled investigation and review of spike counting as a methodology for assessing the antiepileptic effect of drugs. Epilepsy Res. 1990 Apr;5(3):247-50. doi: 10.1016/0920-1211(90)90046-x. PMID: 2384080.