Synonym
Deamino-hydroxytamoxifen; Deamino hydroxytamoxifen; Tamoxifen metabolite Y; Tamoxifen-ol.
IUPAC/Chemical Name
Ethanol, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-, (Z)-
InChi Key
TWASUFZMILCYJY-VHXPQNKSSA-N
InChi Code
InChI=1S/C24H24O2/c1-2-23(19-9-5-3-6-10-19)24(20-11-7-4-8-12-20)21-13-15-22(16-14-21)26-18-17-25/h3-16,25H,2,17-18H2,1H3/b24-23-
SMILES Code
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCO)C=C2)\C3=CC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
44.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fried KM, Wainer IW. Direct determination of tamoxifen and its four major metabolites in plasma using coupled column high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1994 May 13;655(2):261-8. PubMed PMID: 8081472.
2: Langan-Fahey SM, Tormey DC, Jordan VC. Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer. Eur J Cancer. 1990;26(8):883-8. PubMed PMID: 2145931.
3: Etienne MC, Milano G, Fischel JL, Frenay M, François E, Formento JL, Gioanni J, Namer M. Tamoxifen metabolism: pharmacokinetic and in vitro study. Br J Cancer. 1989 Jul;60(1):30-5. PubMed PMID: 2803912; PubMed Central PMCID: PMC2247345.
4: Milano G, Etienne MC, Frenay M, Khater R, Formento JL, Renee N, Moll JL, Francoual M, Berto M, Namer M. Optimised analysis of tamoxifen and its main metabolites in the plasma and cytosol of mammary tumours. Br J Cancer. 1987 May;55(5):509-12. PubMed PMID: 3606944; PubMed Central PMCID: PMC2001713.
5: Murphy C, Fotsis T, Pantzar P, Adlercreutz H, Martin F. Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). J Steroid Biochem. 1987 May;26(5):547-55. PubMed PMID: 3586671.
